Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing
Patent
1996-09-20
1998-01-27
Allen, Marianne P.
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
424 92, 435 72, 435 721, A61K 4900, G01N 3100
Patent
active
057119325
ABSTRACT:
The method of testing the affect of neuroactive agents on cellular receptors is disclosed. The procedures comprise decapitating an invertebrate, in the disclosed tests a Drosophila melanogaster is used. A selected neuroactive agent is applied directly to the severed nerve cord of the invertebrate. The reaction of the invertebrate is observed in response to the application of the agent. The reaction of the invertebrate is an indication of the activities of the cellular receptors which react to the specific agents. The tested agents include dopamine, serotonin and octopamine and vertebrate drugs that act as D1-like receptor agonists, D1-like receptor antagonists, D2-like receptor agonists and D2-like receptor antagonist, and a vertebrate monoamine oxidase inhibitor. Other types of neuroactive agents are also used.
REFERENCES:
Zill, Journal of Neurobiolgy, 17(4):317-328; 1986.
Bicker et al, Nature, 337:33-39, 1989.
Goudey-Perriere, Comp. Biochem. Physiol., 108A(4):533-542, 1994.
Kravitz, Science, 241:1775-1781, 1988.
Tunnicliff et al, Comp. Biochem. Physiol., 29:1239-1245, 1969.
Murphy et al, The Journal of Comparative Neurology, 290:185-200, 1989.
Grossfield, New York Entomological Society, LXXXV(3):119-126, 1977.
Jurenka et al, Insect Biochem, 21(1):81-89, 1991.
Wicker et al, J. Insect Physiol., 41(1):65-70, 1995.
Truman et al, J. Exp. Biol., 61:47-55, 1974.
Valles et al, The Journal of Comparative Neurology, 268:414-428, 1988.
Carrow et al, J. Insect Physiol., 28(5):401-404, 1982.
Hen, Comparative Molecular Neurobiology, ed. Y. Pichon., pp. 266-278, 1993.
Monastirioti et al, The Journal of Comparative Neurology, 356:275-287, 1995.
Yellman et al, Proc. Natl. Acad. Sci, 94:4131-4136, 1997.
Nijhout et al, J. Insect. Physiol., 24:293-298, 1978.
Saudou et al, The EMBO Journal, 11(1):7-17, 1992.
Burg et al, Journal of Neurobiology, 24(6):803-823, (1993).
Goudey-Perriere et al, Comp. Biochem. Physiol., 98C(2/3):407-410, 1991.
Hirsh Jay
Yellman Chris Martin
Allen Marianne P.
Duffy Patricia A.
Parker Sheldon H.
LandOfFree
Screening procedure for neuroactive agents does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Screening procedure for neuroactive agents, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Screening procedure for neuroactive agents will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-339508