Combinatorial chemistry technology: method – library – apparatus – Method of creating a library
Reexamination Certificate
2008-05-06
2008-05-06
Shibuya, Mark L. (Department: 1639)
Combinatorial chemistry technology: method, library, apparatus
Method of creating a library
C435S007100
Reexamination Certificate
active
11358815
ABSTRACT:
A method of producing a chemical compound library comprises extracting at least one extract from at least one species of plant; processing at least one of the extract(s) to remove at least one type of chemical interference to produce a processed extract; chromatographically separating the processed extract into a plurality of chromatographic fractions, each containing an amount of chemical compounds; determining the amount of chemical compounds in at least one of the chromatographic fractions; and normalizing the chromatographic fractions in which the amounts were determined to produce normalized chromatographic fractions, each such fraction comprising from about 1 microgram to about 500 micrograms of each of from one to seven chemical compounds that were present in lower concentrations in the extract and that each have a log P of from about −1 to about 5 and a molecular weight less than about 1000 Daltons; thereby to produce a chemical compound library from at least one species of plant.
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Cremin Peader
Eldridge Gary
Ghanem Marilyn
Lee Chris
Vervoort Helene C.
Gallop, Johnson & Neuman, L.C.
Sequoia Sciences, Inc.
Shibuya Mark L.
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