Screening of candidates for biological hair care activity

Details Screening of candidates for biological hair care activity Screening of candidates for biological hair care activity

1996-07-12

1998-01-27

Sisson, Bradley L.

Chemistry: analytical and immunological testing

Biospecific ligand binding assay

Utilizing isolate of tissue or organ as binding agent

436501, 424 91, 424 62, 424 701, 424 706, 424 708, 424 7011, 424 7019, 424 74, 435 4052, 4352402, G01N 33567, A61K 4900, A61K 706, C12N 500

Patent

active

057121699

ABSTRACT:
A procedure for screening a candidate substance for biological hair care activity comprises (i) microdissecting and isolating at least one viable hair follicle and the epidermal surroundings thereof, while preserving the continuity of such at least one hair follicle and the epidermal environment thereof, but removing the adipose tissue therefrom, (ii) incubating the at least one hair follicle in a nutrient medium for a given period of time, (iii) contacting the at least one incubated hair follicle with the candidate substance for biological hair care activity, and (iv) measuring a marker of the hair care activity of the candidate substance and thence evaluating the results of such measurement in comparison with a control.

REFERENCES:
patent: 5229271 (1993-07-01), Philpott
Developmental Biology, vol. 165, 1994 New York, N.Y., pp. 469-479.
British Journal of Dermatology, vol. 131, No. 1, Jul. 1994 Oxford, pp. 166-176.
Journal of Anatomy, vol. 185, Dec. 1994 Cambridge, pp. 135-142.

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