Screening methods using an atpase protein from hepatitis C virus

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving virus or bacteriophage

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435 21, C12Q 170

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active

060108487

ABSTRACT:
Disclosed are screening methods to identify molecules which activate or inhibit the activity of an ATPase protein of the Flaviviridae family, particularly NS4B protein of Hepatitis C Virus (HCV). These inhibitors and activators of HCV NS4B protein potentially can be used as antiviral compounds and as therapeutic agents for the treatment of viruses linked to the Flaviviridae family, particularly HCV, flaviviruses such as yellow fever virus, Dengue virus types 1-4, and pestiviruses such as bovine viral diarrhea virus and classic swine fever, among others.

REFERENCES:
Neddermann, et al., "The Nonstructural Proteins of the Hepatitis C Virus: Structure and Functions," Biol. Chem. 378:469-476, (1997).
Database Caplux on STN, AN 1996: 628463. Takeshita, et al., Aug. 13, 1996. Jpn. Kikai Tokkyo Koho 13 11.

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