Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2006-09-12
2006-09-12
Johannsen, Diana B. (Department: 1634)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C435S287200, C435S448000, C424S009200
Reexamination Certificate
active
07105292
ABSTRACT:
The cellular response to ultraviolet radiation exposure has been characterized on the molecular level through the use of high density gene array technology. Nucleic acid molecules and protein molecules, the expression of which are repressed or induced in response to ultraviolet radiation exposure, are identified according to a temporal pattern of altered expression post ultraviolet radiation exposure. Methods are disclosed that utilized these ultraviolet radiation-regulated molecules as markers for ultraviolet radiation exposure. Other screening methods of the invention are designed for the identification of compounds that modulate the response of a cell to ultraviolet radiation exposure. The invention also provides compositions useful for drug screening or pharmaceutical purposes.
REFERENCES:
patent: 5770581 (1998-06-01), Weichselbaum et al.
patent: 5908836 (1999-06-01), Bar-Shalom et al.
patent: 5916880 (1999-06-01), Bar-Shalom et al.
patent: 5939082 (1999-08-01), Oblong et al.
patent: 5939457 (1999-08-01), Miser
patent: 5962534 (1999-10-01), Gudas et al.
patent: 6258536 (2001-07-01), Oliner et al.
patent: 6794137 (2004-09-01), Blumenberg
patent: 1 085 093 (2001-03-01), None
Blattner, C. et al. UV-induced stabilization of c-fos and other short-lived mRNAs. Molecular and Cellular Biology 20(10):3616-3625 (May 2000).
Trautinger, F. et al. Stress proteins in the cellular response to ultraviolet radiation. Journal of Photochemistry and Photobiology B: Biology 35:141-148 (1996).
Amundson, S.A. et al. Fluorescent cDNA microarray hybridization reveals complexity and heterogeneity of cellular genotoxic stress responses. Oncogene 18(24):3666-3672 (Jun. 1999).
Latkowski et al., “Epidermal Cell Kinetics, Epidermal Differentiation, and Keratinization,” Fitzpatrick's Dermatology in Medicine (book) 1999 McGraw Hill pp. 133-144.
Herrlich et al., “The Mammalian UV Response: Mechanism of DNA Damage Induced Gene Expression,” Advan. Enzyme Regul. vol. 34, 1995, 381-395.
Ullrich et al., “The Role of Cytokines in UV-Induced Systemic Immune Suppression,” Journal of Dermatological Science, vol. 23, 2000 Abstract.
Ouhtit et al., “Temporal Events in Skin Injury and the Early Adaptive Responses in Ultraviolet-Irradiated Mouse Skin,” American Journal of Pathology, vol. 156, No. 1, Jan. 2000, pp. 201-207.
Beissert et al., “Mechanisms Involved in Ultraviolet Light-Induced Immunosuppression,” J. Investig. Dermatol. Symp. Proc., vol. 4, No. 1, pp. 61-63, 1999.
Zhuang et al., “Molecular Mechanism of Ultraviolet-Induced Keratinocyte Apoptosis,” Journal of Interferon and Cytokine Research, vol. 20, 2000, pp. 445-454.
Assefa et al., “Differential Stimulation of ERK and JNK Activities by Ultraviolet B Irradiation and Epidermal Growth Factor in Human Keratinocytes,” vol. 108, No. 6, Jun. 1997, pp. 886-890.
Kligman et al., “The Nature of Photoaging: Its Prevention and Repair,” Photodermatology, vol. 3, 1986, pp. 215-227.
Lavker et al., “Aged Skin: A Study by Light, Transmission Electron, and Scanning Electron Microscopy,” The Journal of Investigative Dermatology, vol. 88, No. 3, 1987.
Lavker et al., “Structural Alterations in Exposed and Unexposed Aged Skin,” The Journal of Investigative Dermatology, vol. 73, No. 1, pp. 59-66, 1979.
Gilchrest, “Skin and Aging Process” (Book) Copyright 1984 by CRC Press, Inc.
Derijard et al., “JNK1: A Protein Kinase Stimulated by UV Light and Ha-Ras That Binds and Phosphorylates the c-Jun Activation Domain,” Cell, vol. 76, pp. 1025-1037, Mar. 25, 1994.
Kyriakis et al., “The Stress-Activated Protein Kinase Subfamily of c-Jun Kinases,” Nature, vol. 369, pp. 156-160, May 12, 1994.
Rosette et al., “Ultraviolet Light and Osmotic Stress: Activation of the JNK Cascade Through Multiple Growth Factor and Cytokine Receptors,” Science, vol. 274, Issue 5290, Nov. 15, 1996, pp. 1194-1197.
Cavigelli et al., “The Tumor Promoter Arsenite Stimulates AP-1 Activity by Inhibiting a JNK Phosphatase,” The EMBO Journal, vol. 15, No. 22, pp. 6269-6279, 1996.
Kallunki et al., “c-Jun Can Recruit JNK to Phosphorylate Dimerization Partners via Specific Docking Interactions,” Cell, vol. 87, pp. 929-939, Nov. 29, 1996.
Fanger et al., “MEKKs, GCks, MLKs, PAKs, TAKs and Tpls: Upstream Regulators of the c-Jun Amino-Terminal Kinases,” Oncogenes and Cell Proliferation, pp. 67-74.
Devary et al., “NK-$/kappa$B Activation by Ultraviolet Light Not Dependent on a Nuclear Signal,” Science, vol. 261, Sep. 10, 1993, pp. 1441-1445.
Simon et al., “UVB Light Induces Nuclear Factor kB (NFkB) Activity Independently From Chromosomal DNA Damage in Cell-Free Cytosolic Extracts,” The Society for Investigative Dermatology, vol. 102, No. 4, Apr. 1994, pp. 422-427.
Barnes et al., “Mechanisms of Disease,” The New England Journal of Medicine, vol. 336, No. 15, Apr. 10, 1997, pp. 1066-1071.
Li et al., “Ionizing Radiation and Short Wavelength UV Activate NF-$/kappa$B Through Two Distinct Mechanisms,” Proceedings of the National Academy of Science of the United States of America, vol. 95, Issue 22, Oct. 27, 1998, pp. 13012-13017.
Garmyn et al., “Immediate and Delayed Molecular Response of Human Keratinocytes to Solar-Simulated Irradiation,” Laboratory Investigation, vol. 65, No. 4, 1991, pp. 471-478.
Abts et al., “Analysis of UVB-modulated Gene Expression in Human Keratinocytes by mRNA Differential Display Polymerase Chain Reaction,” Photochemistry and Photobiology, vol. 66, No. 3, 1997, pp. 363-367.
Eller, “Photodamage (book)” Blackwell Ed. 1995, pp. 26-56.
Lockhart et al., “Expression Monitoring by Hybridization to High-Density Oligonucleotide Arrays,” Nature Biotechnology, vol. 14, Dec. 1996, pp. 1675-1680.
Johnston et al., “Gene Chips: Array of Hope for Understanding Gene Regulation,” Current Biology, vol. 8, 1998, pp. R171-R174.
Scherf et al., “A Gene Expression Database for the Molecular Pharmacology of Cancer,” Nature Genetics, vol. 24, Mar. 2000, pp. 236-244.
Ross et al., “Systematic Variation in Gene Expression Patterns in Human Cancer Cell Lines,” Nature Genetics, vol. 24, Mar. 2000, pp. 227-235.
Welford et al., “Detection of Differentially Expressed Genes in Primary Tumor Tissues Using Representational Differences Analysis Coupled to Microarray Hybridization,” Nucleic Acids Research, vol. 26, No. 12, 1998, 3059-3065.
Alon et al., “Broad Patterns of Gene Expression Revealed by Clustering Analysis of Tumor and Normal Colon Tissues Probed by Oligonucloetide Arrays,” Proceedings of the National Academy of Sciences of the United States of America, vol. 96, Issue 12, Jun. 8, 1999, pp. 6745-6750.
Golub et al., “Molecular Classification of Cancer: Class Discovery and Class Prediction by Gene Expression Monitoring,” Science, vol. 286, Oct. 15, 1999, pp. 531-537.
Fambrough et al., Diverse Signaling Pathways Activated by Growth Factor Receptors Induce Broadly Overlapping, Rather Than Independent, Sets of Genes, Cell, vol. 97, Jun. 11, 1999, pp. 727-741.
Galitski et al., “Ploidy Regulaton of Gene Expression,” Science, vol. 285, Jul. 9, 1999, pp. 251-253.
Lee et al., “Gene Expression Profile of Aging and Its Retardation by Caloric Restriction,” Science, vol. 285, Aug. 27, 1999, pp. 1390-1392.
Ly et al., “Mitotic Misregulation and Human Aging,” Science, vol. 287, Mar. 31, 2000, pp. 2486-2492.
Harkin et al., “Induction of GADD45 and JNK/SAPK-Dependent Apoptosis Following Inducible Expression of BRCA1,” Cell, vol. 97, May 28, 1999, pp. 575-586.
Jelinsky et al., “Global Response ofSaccharomyces cerevisiaeto an Alkylating Agent,” Proceedings of the National Academy of Sciences of the United States of America, vol. 96, Issue 4, Feb. 16, 1999, pp. 1486
Johannsen Diana B.
New York University
Wilmer Cutler Pickering Hale and Dorr
LandOfFree
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