Screening methods for the identification of inducers and inhibit

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

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435 15, 436516, G01N 3353, G01N 3561, C12Q 112

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058342168

ABSTRACT:
Methods for the identification of inducers and inhibitors of apoptosis are described. The method exploits the finding that the exposure of cells to apoptotic stress and its concurrent shutdown of cellular protein synthesis is accompanied by phosphorylation of IF-2.alpha. and a novel protein termed p90.

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