Screening methods for the identification of compounds that modul

Details Screening methods for the identification of compounds that modul Screening methods for the identification of compounds that modul

1996-12-27

1999-11-02

Scheiner, Laurie

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving virus or bacteriophage

435375, C12Q 170

Patent

active

059767863

ABSTRACT:
Disclosed is a method to limit infection by an immunodeficiency virus. The method includes inhibiting an immunodeficiency virus protein which regulates apoptosis in cells. Also disclosed are methods to identify compounds that regulate cellular inhibitors of apoptosis in cells infected with an immunodeficiency virus and compounds identified thereby.

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Finkel et al., 1995, "Apoptosis occurs predominantly in bystander cells and not in productively infected cells of HIV- and SIV-infected lymph nodes", Nature Med. 1:129-134.
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