Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving virus or bacteriophage
Reexamination Certificate
2004-12-22
2009-02-03
Parkin, Jeffrey S. (Department: 1648)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving virus or bacteriophage
C424S208100
Reexamination Certificate
active
07485416
ABSTRACT:
The present invention provides treatment methods involving modulating a sirtuin activity and/or a sirtuin mRNA and/or a sirtuin polypeptide level. In some embodiments, the present invention provides treatment methods involving modulating SIRT1 activity and/or SIRT mRNA and/or polypeptide level. The present invention provides methods of inhibiting SIRT1 Tat deacetylase activity. Methods of inhibiting SIRT1 Tat deacetylase activity are useful for treating immunodeficiency virus infections, particularly human immunodeficiency virus (HIV) infection. Thus, the present invention provides methods of treating an immunodeficiency virus infection, generally involving inhibiting SIRT1 Tat deacetylase activity. The present invention further provides methods of identifying agents that modulate sirtuin activity (e.g., SIRT1 activity), particularly ability of sirtuins to interact with (e.g., bind and/or deacetylate) a substrate, e.g., a viral substrate such as a Tat polypeptide. The present invention further provides active agents that modulate sirtuin activity or expression; and compositions, including pharmaceutical compositions, comprising the active agents.
REFERENCES:
patent: 2003/0082668 (2003-05-01), Tamai et al.
patent: WO 03/046207 (2003-06-01), None
Voelter-Mahlknecht, S., and U. Mahlknecht, 2006, Cloning, chromosomal characterization and mapping of the NAD-dependent histone deacetylases gene sirtuin 1, Intl. J. Mol. Med. 17:59-67.
Pagans, S., et al. SIRT1 regulates HIV transcription via tat deacetylation. PLoS Biology. 2005, vol. 3, No. 2, pp. 210-220.
Posakony, J., et al. Inhibitors of Sir2: Evaluation of splitomicin analogues. Journal of Medicinal Chemistry. 2004, vol. 47, pp. 2635-2644.
Rettinger, J., et al. The suramin analogue NF279 is a novel and potent antagonist selective for the P2X1 receptor. Neuropharmacology. 2000, vol. 39, pp. 2044-2053.
Sauve, A., et al. The biochemistry of sirtuins. Annual Review of Biochemistry. 2006, vol. 75, pp. 435-465.
Soto, F., et al. Anatagonistic properties of the suramin analogue NF023 at heterologously expressed P2X receptors. Neuropharmacology. 1999, vol. 38, pp. 141-149.
“SIRT1 Deacetylates the HIV Tat Protein and is Required for Tat-Mediated Transactivation of the HIV Promoter” Title, Workshop 1, Molecular Mechanisms of HIV Pathogenesis, Keystone Symposia, Whistler, British Columbia, [online] Apr. 12-18, 2004. Retrieved from the internet: URL: http://www.keystonesymposia.org/Meetings/ViewPastMeetings.cfm?MeetingID=694> [retrieved on Dec. 3, 2007].
Bedalov et al. (2001) Proc. Natl. Acad. Sci. USA 98:15113-15118.
Rusnati et al. (1998) J. Biol. Chem. 273:16027-16037.
Bitterman et al. (2002) J. Biol. Chem. 277:45099-45107.
Hirao et al. (2003) J. Biol. Chem. 278:52773-52782.
Kwon et al. Human immunodeficiency virus type 1 Tat protein inhibits the SIRT1 deacetylase and induces T cell hyperactivation. Cell Host Microbe. Mar. 13, 2008;3(3):158-67.
Jung Manfred
Ott Melanie
Verdin Eric M.
Borden Paula A.
Bozicevic Field & Francis LLP
Parkin Jeffrey S.
The Regents of the University of California
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