Screening methods for immunosuppressive agents

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

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435 71, 435 915, 4352402, 4351723, 536 241, 436 63, 436501, 935 6, 935 17, 935 36, 935 78, 935 77, C12Q 168, C12P 1934, G01N 3353, C07H 2104

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059898100

ABSTRACT:
Activation of NF-AT-dependent transcription, including agents which interfere with the production, modification of the nuclear or cytoplasmic subunits, or the nuclear import of the cytoplasmic subunits. In particular, screening tests for novel immunosuppressants are provided based upon the ability of NF-AT to activate transcription.

REFERENCES:
Verwiej et al J. Biol Chem (1990) 265:15788-15795.
Sambrook et al, Molecular Cloning: A Laboratory Manual, 1989, Cold Spring Harbor Laboratory Press, NY, pp. 10.31-10.33.
Sawadogo et al, Cell (1985) 43:165-175.
Emmel et al Science (1989) 246:1617-1619
Shaw et al. Science (1988) 241:202-205.

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