Screening methods for identifying agents that modulate...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Reexamination Certificate

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C436S501000

Reexamination Certificate

active

07598048

ABSTRACT:
The invention provides a method for screening for a compound for modulating circadian rhythm. The method involves (a) providing a compound that is a Prokineticin 2 (PK2) receptor antagonist or agonist; and (b) determining the ability of the compound to modulate one or more indicia of circadian rhythm function, wherein a compound that modulates one or more indicia of circadian rhythm function is identified as a compound for modulating circadian rhythm. The invention also provides a mouse PK2 receptor nucleic acid, polypeptide and related compositions. Further provided is a method for modulating circadian rhythm of an animal, which involves administering an effective amount of a PK2 receptor antagonist or agonist to an animal. Also provided is an isolated nucleic acid comprising a PK2 gene promoter operatively linked to a heterologous nucleotide sequence.

REFERENCES:
patent: 5545549 (1996-08-01), Gerald et al.
patent: 5621079 (1997-04-01), Cascieri et al.
patent: 2003/0235535 (2003-12-01), Zhou et al.
patent: 2004/0241757 (2004-12-01), Matsumoto et al.
patent: 2006/0172935 (2006-08-01), Zhou et al.
patent: WO 95/35320 (1995-12-01), None
patent: 9846620 (1998-10-01), None
patent: WO 98/46620 (1998-10-01), None
patent: WO 02/00711 (2002-01-01), None
Dunlap 1999. Cell 96:271-290.
Mintz 1999. Journal of Neuroscience 19:5124-5130.
Schwartz 1987. Proc Natl Acad Sci USA 84:1694-1698.
Akiyama 1999. Journal of Neuroscience 19:1115-1121.
Harrington 1997. Neuroreport 8:2677-2680.
Huhman 1996. Neuroreport 7:1249-1252.
Sweetnam 1995. Chapter 17 in Burger's Medicinal Chemictry and Drug Discovery, Fifth Edition, vol. 1, pp. 697-731.
Lowrey 2000. Science 288:483-491.
Turek et al. 1995. Frontiers in Neuroendocrinology 16:191-223.
Edelstein 2001. Brain Research 918:107-112.
Mrosovsky 1999. Chronobiology International 16:415-429.
Silver et al. 1996 Nature 382:810-813.
Reppert 2000. Seminars in Perinatology 24:243-246.
Jud et al. 2005. Biol. Proced. Online 7:101-116.
Li et al. 2006. Journal of Neuroscience 26:11615-11623.
Levine et al. 2002. Signal analysis of behavioral and molecular cycles. BMC Neuroscience 3:1-25.
Albers et al. 1984 Science 223:833-835.
Stoynev et al. 1996. Acta Physiol Pharmacol Bulg 22:39-43.
Harrington, Mary E. and Hoque, Sabina, “NPY Opposes PACAP phase shifts via receptors different from those involved in NPY Phase Shifts”,Neuroreport, vol. 8, pp. 2677-2680, 1997.
Huhman, Kim L. et al., “Neuropeptide Y phase shifts circadian rhythms in vivo via a Y2receptor”,Neuroreport, vol. 7, pp. 1249-1252, 1996.
Lowrey, Phillip L. et al., “Positional Syntenic Cloning and Functional Characterization of the Mammalian Circadian Mutationtau ”, Science, vol. 288, pp. 483-491, 2000.
Sweetnam, Paul M. et al., “Mass Ligand Screening as a Tool for Drug Discovery and Development”,Burger's Medicinal Chemistry and Drug Discovery, Fifth Edition, vol. 1, Chapter 17, pp. 697-731, 1995.
Boer, G. J. et al., “Vasopressin-Deficient Suprachiasmatic Nucleus Grafts Re-Instate Circadian Rhythmicity in Suprachiasmatic Nucleus-Lesioned Arrhythmic Rats”,Neuroscience, vol. 89, pp. 375-385, 1999.
Cheng, M. Y. et al., “Prokineticin 2 transmits the behavioural circadian rhythm of the suprachiasmatic nucleus”,Nature, vol. 417, pp. 405-410, 2002.
Jin, X. et al., “A Molecular Mechanism Regulating Rhythmic Output from the Suprachiasmatic Circadian Clock”,Cell, vol. 96, pp. 57-68, 1999.
Kalsbeeck, A. et al., “A Diurnal Rhythm of Stimulatory Input to the Hypothamamo-Pituitary-Adrenal System as Revealed by Timed Intrahypothalamic Administration of the Vasopressin V1 Antagonist”,The Journal of Neuroscience, vol. 17, pp. 5555-5565, 1996.
Kalsbeek, A. et al., “Vasopressin-containing neurons of the suprachiasmatic nuclei inhibit corticosterone release”,Brain Research, vol. 580, pp. 62-67, 1992.
Li et al., “Identification of Two Prokineticin cDNAs: Recombinant Proteins Potently Contract Gastrointestinal Smooth Muscle”,Molecular Pharmacology, 59:692-698 (2001).
Lin et al., “Identification and Molecular Characterization of Two Closely Related G Protein-Coupled Receptors Activated by Prokineticins/Endocrine Gland Vascular Endothelial Growth Factor”,The Journal of Biological Chemistry, 277(22):19276-19280 (2002).
Melchiorri et al., “The Mammalian Homologue of the Novel Peptide Bv8 is Expressed in the Central Nervous System and Supports Neuronal Survival by Activation the Map Kinase/PI-3-Kinase Pathways”,European Journal of Neuroscience, 13:1694-1702 (2001).
Parker et al., “Y-Receptor-Like Genes GPR72 and GPR73: Molecular Cloning, Genomic Organization and Assignment to Human Chromosome 11q21.1 and 2p14 and Mouse Chromosome 9 and 6”,Biochimica et Biophysica Acta, 1491:369-375 (2000).

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