Screening methods for compounds useful in the regulation of body

Multicellular living organisms and unmodified parts thereof and – Nonhuman animal

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4351723, C12N 1500, C12N 1509

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059327790

ABSTRACT:
The present invention relates to drug screening assays, and diagnostic and therapeutic methods for the treatment of body weight disorders, such as obesity, anorexia and cachexia, utilizing the melanocortin 4-receptor (MC4-R) as the target for intervention. The invention also relates to compounds that modulate the activity or expression of the MC4-R, and the use of such compounds in the treatment of body weight disorders.

REFERENCES:
Xue, B. et al., 1997, "The agouti gene product stimulates pancreatic beta cell Ca.sup.2+ signaling and insulin release", FASEB Journal 11(3):A230.
Zemel, M.B. et al., 1997, "Agouti regulation of leptin expression in adipocytes", FASEB Journal 11(3):A352.
Mynatt, R.L., 1997, "Combined effects of insulin treatment and adipose tissue-specific agouti expression on the development of obesity", PNAS USA 94:919-922.
Boston, B.A. & Cone, R.D., 1996, "Characterization of Melanocortin Receptor Subtype Expression in Murine Adipose Tissues and in the 3T3-L1 Cell Line", Endocron. 137(5):2043-2050.
Boston, B.A. & Cone, R.D., 1996, "Induction of Melanocortin Receptor (MC2-R & MC-R) Expression During Adipocyte Differentiation in the 3T3-L1 Cell Line and Distribution of Expression in Mature Adipose Tissues", Inst. Adv. Biomed. Res. (abstract) 103A.
Cone, R.D. et al., 1996, "The Melanocortin Receptors: Agonists, Antagonists, and the Hormonal Control of Pigmentation", Recent progress in Hormone Res. 51:287-319.
Zemel, M.B. et al., 1996, "Agouti-Induced Obesity is not Antagonized by the Melanocortin Receptor Agonist, NDP-MSH", Obesity Research 4(1):45S.
Manne, J. et al., 1995, "Mechanisms for the pleiotropic effects of the agouti gene", PNAS USA 92:4721-4724.
Willard, D.H., 1995, "Agouti Structure and Function: Characterization of a Potent .alpha.-Melanocyte Stimulating Hormone Receptor Antagonist", Biochem. 34(38):12341-12346.
Zemel, M.B., 1995, "Agouti regulation of intracellular calcium: Role in the insulin resistance of viable yellow mice", PNAS USA 92:4733-4737.
Mountjoy, K.G. et al., 1994, "Localization of the Melanocortin-4 Receptor (MC4-R) in Neuroendocrine and Automatic Control Circuits in the Brain", Mol. Endocrinol. 8(10):1298-1308.
Yen, T. et al., 1994, "Obesity, diabetes, and neoplasia in yellow A.sup.vy /-mice: ectopic expression of the agouti gene", FASEB J. 8:479-488.
Gold, R.M. et al., 1977, "Paraventricular Area: Critical Focus of a Longitudinal Neurocircuitry Mediating Food Intake", Physiol. and Behavior 18:1111-1119.
Brecher, G. et al., 1964, "The Brain Lesion of Goldthioglucose Obesity", Nat. Inst. Arthrit. Metab. Dis. pp. 395-401.
Alvaro, J.D., 1995, "Cloning of the rat melanocortin 4 receptor in brain and its regulation by opiates (locus, coeruleus, ventral tegmentum)", Doctoral Dissertation, Yale University, New Haven, CT, 116 pages.
Mauri, A. et al., 1995, "Melanocortins and opoids modulate early postnatal growth in rats", Regulatory Pep. 59:59-66.
Albanese, C. et al., 1994, "Development of a bioassay for FSH using a recombinant human FSH receptor and a cAMP responsive luciferase reporter gene", Molec. and Cell. Endocrin. 101:211-219.
Hruby et al., 1995, "Cyclic Lactam .alpha.-Melanotropin Analogues of !.alpha.-Melanocyte-Stimulating Hormone-(4-10)-NH .sub.2 with Bulky Aromatic Amino Acids at Position 7 Show High Antagonist Potency and Selectivity at Specific Melanocortin Receptors", J. Med. Chem. 38:3454-3461.
Klebig et al., 1995, "Ectopic Expression of the Agouti Gene in Transgenic Mice Causes Obesity, Features of Type II Diabetes, and Yellow Fur", Proc. Natl. Acad. Sci. USA 92:4728-4732.
Manne et al., 1995, "Mechanisms for the Pleitropic Effects of the Agouti Gene", Proc. Natl. Acad. Sci. USA 92:4721-4724.
Perry et al., 1995, "A Transgenic Mouse Assay for Agouti Protein Activity", Genetics 140:267-274.
Adan et al., 1994, "Identification of Agonists for Melanocortin MC.sup.3, MC.sup.4 and MC.sup.5 Receptors", Eur. J. Pharmacol. 269:331-337.
Ezzell, 1994, "How Chaperonins Monitor Their Protein Charges", J. NIH Res. 6:31-34.
Gantz et al., 1994, "Molecular Cloning, Expression, and Characterization of a Fifth Melanocortin Receptor", Biochem. and Biophys. Res. Comm. 200:1214-1220.
Griffon et al., 1994, "Molecular Cloning and Characterization of the Rat Fifth Melanocortin Receptor", Biochem. and Biophys. Res. Comm. 200:1007-1014.
Labbe et al., 1994, "Molecular Cloning of a Mouse Melanocortin 5 Receptor Gene Widely Expressed in Peripheral Tissues", Biochem. 33:4543-4549.
Low et al., 1994, "Receptors for the Melanocortin Peptides in the Central Nervous System", Curr. Op. in Endocrinol. and Diabetes 1994:79-88.
Lu et al., 1994, "Agouti Protein is an Antagonist of the Melanocyte-Stimulating Hormone Receptor", Nature 371:799-802.
Michaud et al., 1994, "A Molecular Model for the Genetic and Phenotypic Characteristics of the Mouse Lethal Yellow (A.sup.y) Mutation", Proc. Natl. Acad. Sci. USA 91:2526-2566.
Michaud et al., 1994, "Differential Expression of a New Dominant Agouti Allele (A.sup.iapy) is Correlated with Methylation State and is Influenced by Parental Lineage", Genes & Dev. 8:1463-1472.
Mountjoy et al., 1994, "Localization of the Melanocortin-4 Receptor (MC4-R) in Neuroendocrine and Autonomic Control Circuits in the Brain", Mol. Endocrinol. 8:1298-1308.
Siracusa, 1994, "The Agouti Gene: Turned on to Yellow", TIG 10:423-428.
Yen et al., 1994, "Obesity, Diabetes, and Neoplasia in Yellow A.sup.vy /-Mice: Ectopic Expression of the Agouti Gene", FASEB 8:479-488.
Chhajlani et al., 1993, "Molecular Cloning of a Novel Human Melanocortin Receptor", Biochem. and Biophys. Res. Comm. 195:866-873.
Conklin and Bourne, 1993, "Mouse Coat Colour Reconsidered", Nature 364:110.
Gantz et al., 1993, "Molecular Cloning, Expression, and Gene Localization of a Fourth Melanocortin Receptor", J. Biol. Chem. 268:15174-15179.
Jackson, 1993, "Colour-Coded Switches", Nature 362:587-588.
Michaud et al., 1993, "The Embryonic Lethality of Homozygous Lethal Yellow Mice (A.sup.y /A.sup.y) Is Associated with the Disruption of a Novel RNA-Binding Protein", Genes & Dev. 7:1203-1213.
Miller et al., 1993, "Cloning of the Mouse Agouti Gene Predicts a Secreted Protein Ubiquitously Expressed in Mice Carrying the Lethal Yellow Mutation", Genes & Dev. 7:454-467.
Roselli-Rehfuss et al., 1993, "Identification of a Receptor for .gamma.Melanotropin and other Proopiomelanocortin Peptides in the Hypothalamus and Limbic System", Proc. Natl. Acad. Sci. USA 90:8856-8860.
Robbins et al., 1993, "Pigmentation Phenotypes of Variant Extension Locus Alleles Result from Point Mutations that Alter MSH Receptor Function", Cell 72:827-834.
Bultman et al., 1992, "Molecular Characterization of the Mouse Agouti Locus", Cell 71:1195-1204.
Chhajlani and Wikberg, 1992, "Molecular Cloning and Expression of the Human Melanocyte Stimulating Hormone Receptor cDNA", FEBS 309:417-420.
Mountjoy et al., 1992, "The Cloning of a Family of Genes That Encode the Melanocortin Receptors", Science 257:1248-1251.
Shimizu et al., 1989, "Effects of MSH on Food Intake, Body Weight and Coat Color of the Yellow Obese Mouse", Life Sci. 45:543-552.
Frigeri et al., 1988, "Differential Responses of Yellow A.sup.vy /A and Agouti A/a (BALB/c x VY) F, Hybrid Mice to the Same Diets: Glucose Tolerance, Weight Gain, and Adipocyte Cellularity", Int. J. Obesity 12:305-320.
Wolff, 1987, "Body Weight and Cancer", Am. J. Clin. Nutr. 45:168-180.
Wolff et al., 1986, "Prenatal Determination of Obesity, Tumor Susceptibility, and Coat Color Pattern in Viable Yellow (A.sup.vy /a) Mice", J. Heredity 77:151-158.
Wolff et al., 1978, "Phaeomelanin Synthesis and Obesity in Mice", J. Heredity 69:295-298.
Yen et al., 1976, "An Analysis of the Relationships Among Obesity, Plasma Insulin, and Hepatic Lipogenic Enzymes in `Viable Yellow Obese` (A.sup.vy /a)", Horm. Metab. Res. 8:159-166.
Yen et al., 1976, "Triacylglycerol Contents and In Vivo Lipogenesis of Ob/Ob, Db/Db and A.sup.vy /a Mice", Biochimica et Biophysica Acta 441:213-220.
Johnson and Hirsch, 1972, "Cellularity of Adipose Depots in Six Strains of Genetically Obese Mice", J. Lipid Res. 13:2-11.
Yen et

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