Screening Methods

Details Screening Methods Screening Methods

2007-05-08

2007-05-08

Nickol, Gary (Department: 1642)

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Reexamination Certificate

active

09896791

ABSTRACT:
The present invention relates a mammalian polypeptide designated Inhibitory PAS Domain Protein (IPAS) which polypeptide is useful for the inhibition of angiogenesis and/or tumor progression. The invention also relates to screening methods for compounds potentially useful as medicaments for the treatment of medical conditions related to angiogenesis or tumor progression.

REFERENCES:
patent: WO 99/28469 (1999-06-01), None
patent: WO 9928464 (1999-06-01), None
patent: WO 00/09657 (2000-02-01), None
Gu et al. (Gene Expr. vol. 7. No. 3, 1998, pp. 205-213).
Burgess et al., J of Cell Bio. 111:2129-2138, 1990.
Lazar et al. Molecular and Cellular Biology 8:1247-1252, 1988.
Bowie et al. Science, 247:1306-1310, 1990, p. 1306, col. 2.
Gradin et al., “Functional Interference between Hypoxia and Dioxin Signal Transduction Pathways: Competition for Recruitment of the Arnt Transcription Factor,” Mol. Cell. Biol. 16(10):5221-5231 (Oct. 1996).
Guillemin et al., “The Hypoxid Response: Huffing and HIFing,” Cell 89:9-12 (Apr. 4, 1997).
Norton et al., “Id helix-loop-helix proteins in cell growth and differentiation,” Trends in Cell Biology, 8:58-65 (1998).
Wang et al., “Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2tension,” Proc. Natl. Acad. Sci. USA 92:5510-5514 (Jun. 1995).
Wenger et al., “Oxygen(es) and the Hypoxia-Inducible Factor-1,”Biol. Chem. 378(7):609-616 (July 1997).
GenBank Accession No. AI322407, Marra et al., (1998).

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