Screening method using a recombinant kinase insert domain contai

Details Screening method using a recombinant kinase insert domain contai Screening method using a recombinant kinase insert domain contai

1997-02-25

1998-06-16

Walsh, Stephen

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435 78, 435 691, 435325, 435361, 436501, G01N 3353

Patent

active

057668604

ABSTRACT:
A DNA sequence encoding a novel human growth factor receptor referred to as a type III receptor tyrosine kinase is described. The amino acid sequence of the receptor is also described. The receptor has a sequence which is similar to that of the kinase domains of known type III receptor tyrosine kinases, but which is unique in its kinase insert domain sequence. The receptor binds specifically to the vascular endothelial cell growth factor.

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M. Shibuya et al., Oncogene 5:519-524, 1990.

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