Screening method for the identification of bioenhancers through

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

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435 72, 435 4, G01N 33567, G01N 3353, C12Q 100

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active

055675921

ABSTRACT:
A screening method for the identification of bioenhancers that increase the bioavailability of an orally administered pharmaceutical compound through the inhibition of P-glycoprotein transport activity in the gut of a mammal is disclosed. These compounds increase the systemic availability of a pharmaceutical compound when administered prior to, or concurrently with, that compound.

REFERENCES:
patent: 4693966 (1987-09-01), Houghton et al.
patent: 4822816 (1989-04-01), Markham
patent: 4849227 (1989-07-01), Cho
patent: 4944949 (1990-07-01), Story et al.
patent: 4968716 (1990-11-01), Markham
patent: 5070085 (1991-12-01), Markham
patent: 5332747 (1994-07-01), Van Dyke
patent: 5409690 (1995-04-01), Howell et al.
patent: 5436243 (1995-07-01), Sachs et al.
Hunter, J. et al. "Epithelial Secretion of vinblastine by human intestinal adenocarcinoma cell (HCT-8 and T84) layers expressing P-glycoprotein." British Journal of Cancer 64:437-444, 1991.
Arias, I. M. et al. "Structure & function of P-glycoprotein in the normal liver." In: Xenobiotics and Cancer (L. Ernster et al., eds.) Japan Sci. Soc. Press, Tokyo/Taylor & Francis, Ltd, London, 1991, pp. 229-239.
Peters, W. H., et al. "Expression of Drug-Metabolizing Enzymes and p-170 glycoprotein in Colorectal Carcinoma and Normal Mucosa," Gastroenterology 103: 448-455, 1992.
Keller et al., 1992, Int. J. Cancer 51:433-438.
Qian et al., Binding of an Optically Pure Photoaffinity Analogue of Verapamil, LU-49888, to P-Glycoprotein from Multidrug-resistant Human Leukemic Cell Lines, Cancer Research 50:1132-1137, Feb. 15, 1990.
Watkins, 1992, Gastroin. Pharmacol. 21:511-526.
Watkins, 1990, J. Amer. Acad. Dermatol. 23:1301-1311.
Hunter et al., 1991, Br. J. Cancer 64:437-444.
Arias et al., 1991, in Xenobiotics and Cancer (L. Ernster et al., eds.) Japan Sci. Soc. Press, Tokyo, pp. 229-239.
Hsing et al. 1992, Gastroentrol. 102:879-885.
Peters et al., 1992, Gastroenterol. 103:448-455.
Fojo, 1991, Adv. Int. Med. 36:195-218.
Albengres, E., et al., International Journal of Clinical Pharmacology et al., 30/12; 555-570.
Baciewicz, A. M. et al., Archives of Internal Medicine, 153/17; 1970-76.
Back, D. J., et al., British Journal of Clinical Pharmacology, 28; 166-170.
Back, D. J., et al., British Journal of Dermatology, Supplemental; 126; 14-18.
Chan, G. L., et al., Clinical Transplantation, 6/3/1; 141-153.
de Smet, M. D., et al., American Journal of Ophthalmology, 113; 687-690.
First, M. R., et al., The Lancet, 2; 1198-1201.
First, M. R., et al., Transplantation, 51/2; 365-370.
Henricsson, S., et al., Pharmacology & Toxicology, 66; 49-52.
Pichard, L., et al., Drug Metabolism and Disposition, 18/5; 595-606.
Pichard, L., et al., Molecular Pharmacology, 41/6; 1047-1055.
Sands, M., et al., Reviews of Infectious Diseases, 11/1; 691-697.
Sridhar, T. J., et al., Clinical Transplantation, 6/2; 134-138.
Yee, G. C., et al., Clinical Pharmacokinetics, 19/4; 319-332.
Back, David J., and Orme, Michael L'E.; "Pharmacokinetic Drug Interactions with Oral Contraceptives", (1990) Clin. Pharmacokinet. 18(6):472-484.
Callaghan, Richard and Riordan, John R.; "Synthetic and Natural Opiates Interact with P-glycoprotein in Multidrug-resistant Cells", (1993) J. Biol. Chem. 268(21):16059-16064.
Clynes, Martin; "Cellular Models for Multiple Drug Resistance in Cancer", (1993) In Vitro Cell. Dev. Biol. 29A:171-179.
Endicott, Jane A., and Ling, Victor; "The Biochemistry of P-glycoprotein-mediated Multidrug Resistance", (1989) Annu. Rev. Biochem. 58:137-171.
Fahr, Alfred; "Cyclosporin Clinical Pharmacokinetics" (1993) Clin. Pharmacokinetic 24(6):472-495.
Fairchild, Craig R., and Cowan, Kenneth H.; "Keynote Address: Multidrug Resistance: A Pleiotropic Response To Cytotoxic Drugs" (1991) Int. J. Radiation Oncology Biol. Phys. 20:361-367.
Fasco, Michael J. et al.; "Rat Small Intestinal Cytochromes P450 Probed by Warfarin Metabolism" (1993) Mol. Pharmacol. 43:226-233.
Fojo, Antonio T.; "Multidrug Resistance" (1991) Adv. Intern. Med. 36:195-218.
Gatmaitan, Zenaida C. and Arias, Irwin M.; "Structure and Function of P-Glycoprotein in Normal Liver and Small Intestine" (1993) Adv. Pharmacol. 24:77-97.
Greenblatt. David J.; "Presystemic Extraction: Mechanisms and Consequences" (1993) J. Clin. Pharmacol 33:650-656.
Hait, William N. et al.; "Terfenadine (Seldane.RTM.):A New Drug for Restoring Sensitivity to Multidrug Resistant Cancer Cells" (1993) Biochem. Pharmacol 45:401-406.
Hebert, Mary F. et al.; "Bioavailability of Cyclosporine with Concomitant Rifampin Administration is Markedly Less Than Predicted by Hepatic Enzyme Induction" (1992) Clin. Pharmacol. Ther. 52:453-457.
Hsing, Shu et al.; "The Function of Gp170, the Multidrug-Resistance Gene Product. in the Brush Border of Rat Intestinal Mucosa" (1992) Gastroenterology 102:879-885.
Hunter, Janice et al.; "Functional Expression of P-glycoprotein in Apical Membranes of Human Intestinal Caco-2 Cells" (1993) J. Biol. Chem. 268:14991-14997.
Jancis, Erik M. et al.; "Estradiol Induction of Rhodamine 123 Efflux and the Mutidrug Resistance Pump in Rat Pituitary Tumor Cells" (1993) Mol. Pharmachol. 43:51-56.
Kaminsky, Laurence, and Fasco, Michael J.; "Small Intestinal cytochromes P450" (1991) Critical Reviews in Toxicology 21:407-422.
Kolars, Joseph C. et al.; "Identification of Rifampin-inducible P450IIIA4 (CY93A4) in Human Small Bowel Enterocytes" 1992 J. Clin. Invest. 90:1871-1878.
Kolars, Joseph C. et al.; "Heterogeneity fo Cytochrome P450IIIA Expression in Rat Gut Epithelia" (1992) Gastroenterology 102:1186-1198.
Kolars, Joseph C. et al.; "Cyclosporine Metabolism by P450IIIA in Rat Enterocytes--Another Determinant of Oral Bioavailability?" (1992) Transplantation 53:596-602.
Komori, Masayuki et al.; "Cytochrome P-450 in Human Liver Microsomes: High-Performance Liquid Chromatographic Isolation of Three Forms and Their Characterization" (1988) J. Biochem 104:912-916.
Kralovanszky, Judit et al.; "Isolation of Viable Intestinal Epithelial Cell and Their Use for in Vitro Toxicity Studies" (1990) In Vivo 4:201-204.
Kronbach, Thomas et al.; "Cyclosporine Metabolism in Human Liver: Identification of a Cytochrome P450III Gene Family as the Major Cyclosporine-Metabolizing Enzyme Explains Interactions of Cyclosporine With Other Drugs" (1988) Clin. Pharmacol. Ther. 43:630-635.
Kronbach, Thomas et al.; "Oxidation of Midazolam and Triazolam by Human Liver Cytochrome P450IIIA4" (1989) Molec. Pharm. 36:89-96.
Lalka, David et al.; "The Hepatic First-Pass Metabolism of Problematic Drugs" (1993) J. Clin. Pharmacol. 33:657-669.
Ludescher, Christof et al.; "Rapid Functional Assay for the Detection of Multidrug-Resistant Cells Using the Fluorescent Dye Rhodamine 123 (Letter;Comment)" (1991) Blood 78:1385-1387.
Ludescher, Christof et al.; "Detection of Activity of P-Glycoprotein in Human Tumor Samples Using Rhodamine 123" (1992) Br. J. Haematol. 82:161-168.
Lum, Bert L. et al.; "Clinical Trials of Modulation of Multidrug Resistance. Pharmacokinetic and Pharmacodynamic Considerations" (1993) Cancer 72:3502-3514.
Lum, Bert L. et al.; "Molecular Targets in Oncology: Implications of the Multidrug Resistance Gene" (1993) Pharmacotherapy 13:88-109.
Muranishi, Shozo; "Absorbtion Enhancers" (1990) Crit. Rev. Ther. Drug Carrier Sys. 7:1-33.
Nielsen, Dorte et al.; "P-Glycoprotein as Multidrug Transporter: A Critical Review of Current Multidrug Resistant Cell Lines" (1992) Biochim. Biophys. Acta. 1139:169-183.
Pearce, H. L. et al.; "Essential Features of the P-Glycoprotein Pharmacophore as Defined by a Series of Reserpine Analogs That Modulate Multidrug Resistance" (1989) Proc. Natl. Acad. Sci. 86:5128-5132.
Pichard, Lydiane et al.; "Cyclosporine A Drug Interactions: Screening for Inducers and Inhibitors of Cytochrome P-450 (Cyclosporine A Oxidase) in Primary Cultures of Human Hepatocytes and in Liver Microsomes" (1990) Drug. Metab. Dipos. 18:595-606.
Schmiedlin-Ren, Phyllissa et al.; "Cultured Adult Rat Jejunal Explants as a Model for Studying Regulation of CYP3A" (1993) Biochem. Pharmacol. 46:905-918.
Somberg, John et al.; "The Clinical Implications of First-Pass Metabolism: Treatmen

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