Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving virus or bacteriophage
Reexamination Certificate
2006-06-27
2006-06-27
Mosher, Mary E. (Department: 1648)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving virus or bacteriophage
C435S023000, C435S029000, C435S032000
Reexamination Certificate
active
07067248
ABSTRACT:
The focus of the present invention is an effective anti-poxvirus drug for use in treating or preventing human disease caused by pathogenic poxviruses. More particularly, the present invention relates to antiviral drugs that target the poxvirus proteinase responsible for core protein maturation, a step which is absolutely essential for the production and spread of infectious virions.
REFERENCES:
Byrd et al (Journal of Virology 78:12147-12156, 2004).
Byrd et al., Journal of Virology (Sep. 2002) vol. 76, No. 17, p. 8973-8976.
Whitehead et al, Journal of Virology (Nov. 1994) vol. 68, No. 11, p. 7603-7608.
Krafft et al., Methods in Enzymology (1994) vol. 241, p. 70-86.
Hellen, Methods in Enzymology (1994) vol. 241, p. 46-58.
Cummings et al., Analytical Biochemistry (1999) vol. 269, p. 79-93.
Flynn et al, Current Opinion in Chemical Biology (1997) vol. 1, No. 2, p. 190-196.
Whitehead et al., “A Transcriptionally Controlled trans-Processing Assay; Putative Identification of a Vaccinia Virus-Encoded Proteinase Which Cleaves Precursor Protein P25K”, Journal of Virology (Nov. 1994) p. 7603-7608, vol. 68, No. 11, American Society for Microbiology, Washington DC.
Byrd et al., The Vaccinia Virus 17L Gene Product is the Core Protein Proteinase, Journal of Virology (Sep. 2002) p. 8973-8976, Vo. 76, No. 17, American Society for Microbiology, Washington DC.
Krafft et al., “Synthetic Approaches to Continuous Assays of Retroviral Proteases”, Methods in Enzymology, vol. 241, p. 70-86, Academic Press, Inc. San Diego, CA and London, England.
Hellen, “Assay Methods for Retroviral Proteases”, Methods in Enzymology, vol. 241, p. 46-58, Academic Press, Inc., San Diego, CA and London, England.
Cummings et al., “Use of a Phosphotyrosine-Antibody Pair as a General Detection Method in Homogeneous Time-Resolved Fluorescence: Application to Human Immunodeficiency Viral Protease”, Analytical Biochemistry, (1999) vol. 269, p. 79-93, Academic Press, San Diego, CA and London, England.
Flynn et al, “Recent Advances in Antiviral Research: Identification of Inhibitors of the Herpesvirus Proteases”, Current Opinion in Chemical Biology (Aug. 1997) Vo. 1, No. 2, p. 190-196.
Bolken Tové C.
Byrd Chelsea
Hruby Dennis E.
Bingham & McCutchen LLP
McGowan Malcolm K.
Mosher Mary E.
Siga Technologies, Inc.
LandOfFree
Screening method for orthopoxvirus antivirals does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Screening method for orthopoxvirus antivirals, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Screening method for orthopoxvirus antivirals will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3680576