Screening method for detecting fetal chromosal abnormalities

Details Screening method for detecting fetal chromosal abnormalities Screening method for detecting fetal chromosal abnormalities

1992-04-14

1994-05-31

Rosen, Sam

Chemistry: analytical and immunological testing

Peptide, protein or amino acid

Glycoproteins

435 79, 435 792, 436 65, 436 86, 436510, 436518, 436548, G01N 3349, G01N 33493

Patent

active

053169530

ABSTRACT:
A screening method for fetal Down syndrome using free beta (HCG) as a marker. The maternal blood level of free beta (HCG) is measured and compared to reference data, at a similar gestational age, of the level of free beta (HCG) in pregnant women carrying a fetus with Down syndrome and pregnant women carrying an unaffected fetus. The method may advantageously be utilized during the first and second trimesters of pregnancy. Fragments of free beta and "nicked" free beta may also be utilized as markers.

REFERENCES:
Arab et al-Biological Abstracts Report of Meeting 12-15 Oct. 1988, New Orleans, La. (39th Annual Meeting of Am. Soc. of Human Genetics).

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