Screening method for controlling agranulocytosis

Details Screening method for controlling agranulocytosis Screening method for controlling agranulocytosis

1991-12-04

1994-04-05

Wityshyn, Michael G.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

436 63, 436 74, 436815, 424 9, 514255, C12Q 100, G01N 3348

Patent

active

053004221

ABSTRACT:
A screening method for detecting the vulnerability of patients on clozapine therapy to developing agranulocytosis which comprises establishing the concentration of N-desmethylclozapine in the blood or bone marrow of said patient. In addition, a method of determining patient sensitivity to N-desmethylclozapine is provided which comprises collecting heparinized blood and assaying it for stem cell sensitivity to N-desmethylclozapine.

REFERENCES:
patent: 5013735 (1991-05-01), Bjork
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Baldessarini et al, The New England Journal of Medicine, vol. 324, No. 11, pp. 746-754, Mar. 4, 1991.
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