Screening method for candidate drugs

Details Screening method for candidate drugs Screening method for candidate drugs

2007-12-04

2007-12-04

Saunders, David A. (Department: 1644)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

C435S004000, C435S007400, C435S025000, C435S029000, C435S189000, C436S086000, C436S501000, C436S506000, C436S503000, C436S504000, C530S350000, C530S358000, C530S413000

Reexamination Certificate

active

10148496

ABSTRACT:
The present invention relates to methods for screening molecules and methods to detect protein-protein interactions and means used therein. More specifically, the present invention relates to methods for screening candidate drugs for treating or detecting MIF (macrophage migration inhibitor factor) related diseases. In certain aspects, the present invention involves detecting MIF/Jab1 (c-Jun activation domain binding protein) interactions as a basis for modulating cellular regulatory pathways and for identifying candidate drugs for MIF-related diseases. The invention also provides methods for the identification of molecules which dissociate or prevent interaction or binding between MIF and Jab1.

REFERENCES:
patent: 5595885 (1997-01-01), Stetler-Stevenson et al.
patent: 96/32503 (1996-10-01), None
patent: WO98/17314 (1998-04-01), None
patent: 99/24574 (1999-05-01), None
patent: 99/42578 (1999-08-01), None

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