Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2005-02-25
2009-08-11
Horlick, Kenneth R. (Department: 1637)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
Reexamination Certificate
active
07572579
ABSTRACT:
A screening method for a compound which inhibits a ribonuclease H activity of a reverse transcriptase which includes incubating a substrate with an appropriate primer hybridized to an appropriate template, a metal ion and a reverse transcriptase to form a complex, adding a test substance, and after these steps adding dNTPs to initiate DNA synthesis, measuring the amount of nucleic acid cleaved from the template, and comparing the measured value with a measured value in the absence of a test substance.
REFERENCES:
patent: WO-03/103610 (2003-12-01), None
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Shishido Takao
Yoshinaga Tomokaz
Birch & Stewart Kolasch & Birch, LLP
Horlick Kenneth R.
Shionogi & Co. Ltd.
Thomas David C
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