Screening method

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Reexamination Certificate

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C436S501000

Reexamination Certificate

active

07138249

ABSTRACT:
The screening method for a compound or a salt thereof that alters the binding property between Neuromedin U or a salt thereof and TGR-1 or a salt thereof, characterized by using Neuromedin U, a derivative thereof or a salt thereof and TGR-1 or a salt thereof, can be useful for screening a therapeutic and/or prophylactic agent for hypertension and stress-related diseases, etc. A TGR-1 antagonist can be useful as a therapeutic and/or prophylactic agent for hypertension and stress-related diseases, etc.

REFERENCES:
patent: 2003/0148450 (2003-08-01), Chen et al.
patent: WO 99/55732 (1999-11-01), None
patent: WO 00/02919 (2000-01-01), None
patent: WO 00/22131 (2000-04-01), None
patent: WO 00/31258 (2000-06-01), None
patent: WO 01/40797 (2001-06-01), None
patent: WO 01/44297 (2001-06-01), None
patent: WO 01/81418 (2001-11-01), None
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A. Howard, et al. “Identification of Receptors for Neuromedin U and Its Role in Feeding” NATURE 406:70-74(Jul. 6, 2000).
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Rita Raddatz, et al., “Identification and Characterizaiton of two Neuromedin U Receptors Differentially Expressed in Peripheral Tissues and the Central Nervous System”, The Journal of Biological Chemistry (2000), pp. 32452-32459, vol. 275, No. 42, XP002163227.
Ryo Fujii, et al., “Identification of Neuromedin U as the Cognate Ligand of the Orphan G Protein-coupled Receptor FM-3”, The Journal of Biological Chemistry, (2000), pp. 21068-21074, vol. 275, No. 28, XP-002163226.
Funes, S. et al., Cloning and characterization of murine neuromedin U receptors, PEPTIDES 23 (2002) 1607-1615.

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