Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2006-03-21
2006-03-21
Duffy, Patricia A. (Department: 1645)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C435S007240, C435S040500, C424S009100
Reexamination Certificate
active
07014998
ABSTRACT:
Screens that directly or indirectly measure or qualitatively observe CTLA-4 expression or function by animals or cell cultures, or that indirectly measure dependence of an agent on CTLA-4 by comparison to animals or cell cultures that lack CTLA-4, identify agents that are useful in immunosuppression and the generation of immunologic tolerance for the prevention and treatment of transplant rejection, autoimmune and inflammatory diseases.
REFERENCES:
patent: 5434131 (1995-07-01), Linsley et al.
patent: 6024957 (2000-02-01), Lazarovits et al.
patent: 6084067 (2000-07-01), Freeman et al.
patent: 6099838 (2000-08-01), Lazarovits et al.
patent: 6106834 (2000-08-01), Lazarovits et al.
Xia et al. , CMLS Cell. Mul. Life. Sci. 55:1649-56, 1999.
Curreno et al, Journal of Immunology 165:1352-1356, 2000.
Harper et al. (J Immunol 1991 vol. 147(3) pp. 1037-1044).
Fecteau, S., et al., Nature Immunology 2: 58-63 (2001).
Rothstein, D., et al., J. ASN abstract (2000) “A New Paradigm for the Induction of Tolerance”.
Rothstein, D., et al., J. ASN abstract (2000) “Tolerance Induced Through Alteration of Signal One . . . ”.
Rothstein, D., and Basadonna, G., Graft 2: issue 6 immunosuppression review, Nov./Dec. 199: “Anti-CD45”.
Rothstein, D., et al., Journal of Immunology 166: 322-329 (2001).
Tian, J., et al., J. ASN abstract (2001) “CD-45 Mediation Upregulation of the CTLA-4 Inhibitory Receptor . . . ”.
Tivol, E. et al. Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4. Immunity 3, 541-547 (1995).
Waterhouse P., Penninger, J. M., Timms E., Wakeham A., Shahinian A., Lee K. P., Thompson C. B., Griesser, H., & Mak T. W. Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4. Science 270, 985-988 (1995).
Perez, V. L. et al. Induction of peripheral T cell tolerance in vivo requires CTLA-4 engagement. Immunity 6, 411-417 (1997).
Leach, D. R., Krummel, M. F. & Allison, J. P. Enhancement of antitumor immunity by CTLA-4 blockade. Science 271. 1734-1736 (1996).
Luhder, F., Hoglund, P., Allison, J. P., Benoist, C. & Mathis, D. Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) regulates the unfolding of autoimmune diabetes. J. Exp. Med. 187, 427-432 (1998).
Karandikar, N. J., Vanderlugt, C. L., Walunas, T. L., Miller, S. D. & Bluestone, J. A. CTLA-4: A negative regulator of autoimmune disease. J. Exp. Med. 184, 783-788 (1996).
Takahashi, T. et al. Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4. J. Exp. Med. 192, 303-310 (2000).
Judge, T. A. et al. The role of CD80, CD86, and CTLA4 in alloimmune responses and the induction of long-term allograft survival. J. Immunol. 162, 1947-1951 (1999).
Linsley, P. S. et al. Intracellular trafficking of CTLA-4 and focal localization towards sites of TCR engagement. Immunity 4, 535-543 (1996).
Alegre, M. L. et al. Regulation of surface and intracellular expression of CTLA4 on mouse T cells. J. Immunol. 157, 4762-4770 (1996).
Finn, P. W. et al. Synergistic induction of CTLA-4 expression by constimulation with TCR plus CD28 signals mediated by increased transcrption and messenger ribonucleic acid stability. J. Immunol. 158, 4074-4081 (1997).
Krummel, M. F. & Allison, J. P. CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation. J. Exp. Med. 182, 459-465 (1995).
Walunas, T. L. et al. CTLA-4 can function as a negative regulator of T cell activation. Immunity 1, 405-413 (1994).
Trowbridge, I. S. & Thomas, M. L. CD45: An emerging role as a protein tyrosine phosphatase required for lymphocyte activation and development. Ann. Rev. Immunol. 12, 85-116 (1994).
Kashio, N., Matsumoto, W., Parker, S. & Rothstein, D. M. The second domain of the CD45 transmembrane protein tyrosine phosphatase is critical for IL2 secretion and for recruitment of substrates in vivo. J. Biol. Chem. 273, 33856-33863 (1998).
Bottomly, K. et al. A monoclonal antibody to murine CD45R distinguishes CD4 T cell populations that produce different cytokines. Eur. J. Immunol. 19, 617-623 (1989).
Lee, W., Yin, X.-M. & Vitetta, E. Functional and ontogenetic analysis of murine CD45hiand CD45loCD4+T cells. J. Immunol. 144, 3288-3295 (1990).
Powrie, F. et al. Inhibition of Th1 response prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhiCD4+T cells. Immunity 1, 553-562 (1994).
Morimoto, C., Letvin, N. L., Distaso, J. A., Aldrich.W. R. & Schlossman, S. F. The isolation and characterization of the human suppressor inducer T cell subset. J. Immunol. 134, 1508-1515 (1985).
Rothstein, D. M., Yamada, A., Schlossman, S. F. & Morimoto, C. Cyclic regulation of CD45 isoform expression in a long-term human CD4+CD45RA+T cell line. J. Immunol. 146, 1175-1183 (1991).
Sparshott, S. & Bell, E. Membrane CD45R isoform exchange on CD4 T cells is rapid, frequent and dynamic in vivo. Eur. J.Immunol. 24, 2573-2578 (1994).
Michie, C. A., McLean, A., Alcock, C. & Beverly, P. C. L. Lifespan of human lymphocyte subsets defined by CD45 isoforms. Nature 360, 264-265 (1992).
McKenney, D. W., Onodera, H., Gorman, L., Mimura, T. & Rothstein, D. M. Individual isoforms of the CD45 protein tyrosine phosphatase differentially regulate interleukin 2 secretion and activation signal pathways involving Vav in T cells. J. Biol. Chem. 270, 24949-24954 (1995).
Onodera, H., Motto, D.G., Koretzky, G. A. & Rothstein, D. M. Differential Regulation of Activation-Induced Tyrosine Phosphorylation and Recruitment of SLP-76 to Vav by Distinct Isoforms of the CD45 Protein Tyrosine Phosphatase. J. Biol. Chem. 271, 2225-2230 (1996).
Novak, T. et al. Isoforms of the transmembrane tyrosine phosphatase CD45 differentially affect T cell recognition. Immunity 1, 109-119 (1994).
Basadonna, G. et al. Antibody mediated targeting of CD45 isoforms: A novel immunotherapeutic strategy. Proc. Nat. Acad. Sci. USA. 95, 3821-3826 (1998).
Lazárovits, A. et al. Prevention and reversal of renal allograft rejection by antibody against CD45RB. Nature 380, 717-720 (1996).
Metz, D. P., Farber, D. L., Taylor, T. & Bottomly, K. Differential role of CTLA-4 in regulation of resting memory versus naive CD4 T cell activation. J. Immunol. 161, 5855-5861 (1998).
Chuang, E. et al. Interaction of CTLA-4 with the clathrin-associated protein AP50 results in ligand-independent endocytosis that limits cell surface expression. J. Immunol. 159, 144-151 (1997).
Croft, M., Duncan, D. D. & Swain, S. L. Response of naive antigen-specific CD4+T cells in vitro: characteristics and antigen-presenting cell requirements. J. Exp. Med. 176, 1431-1437 (1992).
Liu, J. et al, Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes. Cell 66, 807-815 (1991).
Walunas, T. L. & Bluestone, J. A. CTLA-4 regulates tolerance induction and T cell differentiation in vivo. J. Immunol. 160, 3855-3860 (1998).
Read, S., Malmstrom, V. & Powrie, F. Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25+CD4+regulatory cells that control intestinal inflammation. J. Exp. Med. 192, 295-302 (2000).
Salomon, B. et al. B7/CD28 constimulation is essential for the homeostasis of the CD4+CD25+immunoregulatory T cells that control autoimmune diabetes. Immunity 12, 431-440 (2000).
Perkins, D. et al. Regulation of CTLA-4 expression during T cell activation. J. Immunol. 156, 4154-4159 (1996).
Shiratori, T. et al. Tyrosine phosphorylation controls internalization of CTLA4 by regulating its interaction with clathrin-associated adaptor complex AP-2. Immunity 6, 583-589 (1997).
Schneider, H. et al. Cytolytic T lymphocyte-associated antigen-4 and the TCR /CD3 complex, but not CD28, interact with clathrin adaptor complexes AP-1 and AP-2. J. Immunol. 163, 1868-1879 (1999).
Rothstein, D. M., Saito, H., Streull, M., Schlossman, S. F. & Morimoto, C. The alternative splicing of the CD45
Basadonna Giacomo P.
Rothstein David M.
Carmody & Torrance LLP
Duffy Patricia A.
Yale University
LandOfFree
Screening immunomodulatory agents by CTLA-4 upregulation does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Screening immunomodulatory agents by CTLA-4 upregulation, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Screening immunomodulatory agents by CTLA-4 upregulation will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3546155