Screening for ligand binding at specific target sites

Details Screening for ligand binding at specific target sites Screening for ligand binding at specific target sites

2008-09-02

2008-09-02

Sines, Brian J (Department: 1797)

Chemistry: analytical and immunological testing

Measurement includes temperature change of the material...

C422S050000, C422S051000, C422S068100, C422S082120, C436S043000, C436S174000, C436S175000, C436S180000, C374S031000, C374S032000

Reexamination Certificate

active

10719457

ABSTRACT:
A method for screening of compounds for binding differentiation at various drug target binding sites is used with a device measuring the enthalpy of reaction for the binding. The method includes merging test ligand with target compound and merging test ligand with target compound in the presence of at least one blocking agent. A first heat of reaction is detected for the merged test ligand and target compound solution and a second heat of reaction is detected for the merged test ligand and target compound solution in the presence of a blocking agent. The two heats of reaction are compared to determine whether a reaction has occurred.

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