Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2006-12-18
2010-12-14
Ulm, John D (Department: 1649)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S007200, C435S007210, C436S501000
Reexamination Certificate
active
07851165
ABSTRACT:
A method for screening a test compound for activity in modulating the activity of the chloride channel ClC-7 either directly or by modulating the subcellular localization of Ostm1 comprises determining whether test compound inhibits the binding of Ostm1 to ClC-7. Compounds active in the screen are candidates for use in treating bone resorption conditions such as Osteoporosis by modulating the activity of osteoclasts.
REFERENCES:
patent: 2003/0215787 (2003-11-01), Yang et al.
patent: 2004/0009915 (2004-01-01), Chang et al.
patent: 2004/0219511 (2004-11-01), Liang
patent: WO-02/059356 (2002-08-01), None
patent: WO-02/079414 (2002-10-01), None
C. Blin-Wakkach et al., “Osteopetrosis, from mouse to man”,Medicine Sciences, 20:1, pp. 61-67 (2004).
E. Cleiren et al., “Albers-Schonberg disease (autosomal dominant osteopetrosis, type II) results from mutations in the CICN7 chloride channel gene”,Human Molecular Genetics, 10:25, pp. 2861-2867 (2001).
U. Kornak et al., “Loss of the CIC-7 Chloride Channel Leads to Osteopetrosis in Mice and Men”,Cell, vol. 104, pp. 205-215 (Jan. 26, 2001).
P. Quarello et al., “Clinical Vignette: Severe Malignant Osteopetrosis Caused by a GL Gene Mutation”,Journal of Bone and Mineral Research, 19:7, pp. 1194-1199 (2004).
A. Ramirez et al., “Identification of a Novel Mutation in the Coding Region of the Grey-Lethal Gene OSTM1 in Human Malignant Infantile Osteopetrosis”,Human Mutation, vol. 23, pp. 471-476 (2004).
G.A. Rodan et al., “Therapeutic approaches to bone diseases”,Science, vol. 289, pp. 1508-1514 (2000).
S.L. Teitelbaum et al., “Genetic regulation of osteoclast development and function”,Nature Review—Genetics, vol. 4, pp. 638-649 (2003).
S.L. Teitelbaum et al., “Bone Resorption by Osteoclasts”,Science, vol. 289, pp. 1504-1508 (2000).
H.C. Blair et al., “Passive chloride permeability charge coupled to H+ATPase of avian osteoclast ruffled membrane”,American Physiological Society, vol. 260, pp. C1315-C1324 (1991).
H.C. Blair et al., “Extracellular-matrix degradation at acid pH—Avian osteoclast acid collagenase isolation and characterization”,Biochem. J., 290(3), pp. 873-884 (1993).
H.C. Blair et al., “Osteoclastic Bone Resorption by a Polarized Vacuolar Proton Pump”,Science, vol. 245, pp. 855-857 (1989).
H.C. Blair et al., “Recent Advances Toward Understanding Osteoclast Physiology”,Clinical Orthopaedics and Related Research, No. 294, pp. 7-22 (1993).
Q. Al-Awqati et al., “Chloride Channels of Intracellular Organelles”,Current Opinion Cell Biology, vol. 7, pp. 504-508 (1995).
T. Laitala et al., “Inhibition of Bone Resorption in Vitro by Antisense RNA and DNA Molecules Targeted against Carbonic Anhydrase II or Two Subunits of Vacuolar H+−-ATPase”,J. Clin. Invest., vol. 93, pp. 2311-2318 (1994).
R. Kiviranta et al., “Impaired bone resorption in cathepsin K-deficient mice is partially compensated for by enhanced osteoclastogenesis and increased expression of other proteases via an increased RANKL/OPG ratio”,Bone, vol. 36, pp. 159-172 (2005).
T.J. Jentsch et al., “Physiological Functions of CLC C1- Channels Gleaned from Human Genetic Disease and Mouse Models”,Annu. Rev. Physiol., vol. 67, pp. 779-807 (2005).
T.J. Jentsch et al., “Molecular Structure and Physiological Function of Chloride Channels”,Physiol. Rev., vol. 82, pp. 503-568 (2002).
B. Nilius et al., “Volume-activated C1- Channels”,Gen. Pharmac., 27(7), pp. 1131-1140 (1996).
M.E.M. Kelly et al., “Outwardly rectifying chloride current in rabbit osteoclasts is activated by hyposmotic stimulation”,Journal of Physiology, 475(3), pp. 377-389 (1994).
H. Sakai et al., “Synergetic activation of outwardly rectifying C1- currents by hypotonic stress and external Ca2+ in murine osteoclasts”Journal of Physiology, 515(1), pp. 157-168 (1999).
A.F. Weidema et al., “Electrophysiological characterization of ion channels in osteoclasts isolated from human deciduous teeth”,Bone, 27(1), pp. 5-11 (2000).
A.B. Campos-Xavier et al., “Chloride channel 7 (CLCN7) gene mutations in intermediate autosomal recessive osteopetrosis”,Hum. Genet., vol. 112, pp. 186-189 (2003).
R.J. Daniels et al., “Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16”,Human Molecular Genetics, 10(4), pp. 339-352 (2001).
O. Scheel et al., “Voltage-dependent electrogenic chloride/proton exchange by endosomal CLC proteins”,Nature, vol. 436, pp. 424-427 (2005).
T.J. Jentsch et al., “Physiological functions of CLC C1- channels gleaned from human genetic disease and mouse models”,Annu. Rev. Physiol., vol. 67, pp. 779-807 (2005).
T.J. Jentsch et al., “CLC chloride channels and transporters”,Current Opinion in Neurobiology, vol. 15, pp. 319-325 (2005).
A. Picollo et al., “Chloride/Proton Antiporter Activity of Mammalian CLC Proteins CIC-4 and CIC-5”,Nature, vol. 436, pp. 420-423 (2005).
A. Accardi et al., “Secondary active transport mediated by a prokaryotic homologue of CIC C1- channels”,Nature, vol. 427, pp. 803-807 (2004).
N. Chalhoub et al., “Grey-lethal mutation induces severe malignant autosomal recessive osteopetrosis in mouse and human”,Nature Medicine., 9(4), pp. 399-406 (2003).
D. Kasper et al., “Loss of the chloride channel CIC-7 leads to lysosomal storage disease and neurodegeneration”,The EMBO JoumaJ., vol. 24, pp. 1079-1091 (2005).
R.M. Van Der Hee et al., “Comparison of 3 AT1 receptor binding assays: filtration assay, ScreenReady Target, and WGA Flashplate”,J.oumal of Biomolecular Screening,, 10(2), pp. 118-126 (2005).
K. Crane et al., “Development of a homogeneous binding assay for histamine receptors”,Analytical Biochemstry, vol. 335, pp. 42-49 (2004).
P. Sorensen et al., “Identification of protein-protein interfaces implicated in CD80-CD28 costimulatory signaling”,The Journal of Immunology, vol. 172, pp. 6803-6809 (2004).
M.A. Cooper et al., “Label-free screening of bio-molecular interactions”,Anal Bioanal. Chem., vol. 377, pp. 834-842 (2003).
G.J. Parker et al., “Development of High Throughput Screening Assays Using Fluorescence Polarization: Nuclear Receptor-Ligand-Binding and Kinase/Phosphatase Assays”,J. Biomol. Screen, vol. 5, pp. 77-88 (2000).
R. Seethala et al., “Fluorescence Polarization Competition Immunoassay for Tyrosine Kinases”,Methods, vol. 22, pp. 61-70 (2000).
R. Rigler et al., “Specific binding of proinsulin C-peptide to human cell membranes”,PNAS, 96(23), pp. 13318-13323 (1999).
Y. Liu et al., “Screening of drugs by FRET analysis identifies inhibitors of SARS-CoV 3CL protease”,Biochemical and Biophysical Research Communications, vol. 333, pp. 194-199 (2005).
D. Klostermeier et al., “A three-fluorophore FRET assay for high-throughput screening of small-molecule inhibitors of ribosome assembly”,Nucleic Acids Research, 32(9), pp. 2707-2715 (2004).
B. Sharma et al., “Competitive Binding Assay Using Fluorescence Resonance Energy Transfer for the Identification of Calmodulin Antagonists”,Bioconjugate Chemistry, vol. 16, pp. 1257-1263 (2005).
B. Zhang et al., “Design of FRET-based GFP probes for detection of protease inhibitors”,Biochemical and Biophysical Research Communications, vol. 323, pp. 674-678 (2004).
C. Tahtaoui et al., “On the Use of Nonfluorescent Dye Labeled Ligands in FRET-Based Receptor Binding Studies”,Journal of Medicinal Chemistry, vol. 48, pp. 7847-7859 (2005).
A. Pramanik et al., “Ligand-Receptor Interactions in the Membrane of Cultured Cells Monitored by Fluorescence Correlation Spectroscopy”,Biol. Chem., vol. 382, pp. 371-378 (2001).
T.
Fuhrmann Jens C.
Jentsch Thomas
Lange Philipp
Edwards Angell Palmer & & Dodge LLP
Hunter-Ensor, Esq. Melissa
Lauro, Esq. Peter C.
Pharmos Bioscience A/S
Ulm John D
LandOfFree
Screening compounds for activity in modulating chloride ion... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Screening compounds for activity in modulating chloride ion..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Screening compounds for activity in modulating chloride ion... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4194898