Screening assays to identify agents that modulate cisplatin resi

Details Screening assays to identify agents that modulate cisplatin resi Screening assays to identify agents that modulate cisplatin resi

1997-05-08

1999-01-12

Wax, Robert A.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 723, 435 76, 424 64, 424 86, C12Q 168

Patent

active

058586741

ABSTRACT:
Isolated nucleic acids which can confer on a cell at least a 5-fold increase in cisplatin resistance relative to a cisplatin sensitive cell are disclosed. The nucleic acids of the invention can further confer on a cell resistance to heavy metals such as cadmium and copper. Isolated proteins encoded by the nucleic acids of the invention are also disclosed. The isolated nucleic acids and proteins of the invention are useful for conferring cisplatin resistance on a cell, for example non-malignant cells in a tumor bearing subject being treated with cisplatin. Alternatively, the cisplatin resistance of a cell can be inhibited by contacting the cell with an agent which inhibits the activity of the protein of the invention, for example to reverse the cisplatin resistance of a tumor cell. The invention also discloses methods for identifying substances which inhibit cisplatin resistance in a cell or which are chemosensitizers of cisplatin. The invention further discloses methods for identifying cisplatin resistant tumor cells using the nucleic acids and proteins of the invention.

REFERENCES:
patent: 4861905 (1989-08-01), Nowatari et al.

Affiliated with

Also associated with

Rating

Screening assays to identify agents that modulate cisplatin resi does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Screening assays to identify agents that modulate cisplatin resi, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Screening assays to identify agents that modulate cisplatin resi will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1514111