Screening assays for compounds that inhibit membrane fusion-asso

Details Screening assays for compounds that inhibit membrane fusion-asso Screening assays for compounds that inhibit membrane fusion-asso

1997-09-26

2000-04-25

Stucker, Jeffrey

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving virus or bacteriophage

435 72, C12Q 170

Patent

active

060542659

ABSTRACT:
The present invention relates to peptides which exhibit potent anti-retroviral activity. The peptides of the invention comprise DP178 (SEQ ID:1) peptide corresponding to amino acids 638 to 673 of the HIV-1.sub.LAI gp41 protein, and fragments, analogs and homologs of DP178. The invention further relates to the uses of such peptides as inhibitory of human and non-human retroviral, especially HIV, transmission to uninfected cells.

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