Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1996-07-01
1999-11-16
Tsang, Cecilia J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 13, 514 14, 514 15, 530324, 530326, 530328, A61K 3808, A61K 3816, C07K 706, C07K 1400
Patent
active
059858290
ABSTRACT:
This invention relates to methods of screening for compounds capable of inducing apoptosis in certain tumor cells. The invention also relates to compounds identified by such methods. In addition, the invention relates to methods for the in vitro diagnosis of Xeroderma pigmentosum and compounds useful in these methods.
REFERENCES:
Wang, X.W., et al. (1996) "p53 Tumor Suppressor Gene: at the Crossroads of Molecular Carcinogenesis, Molecular Epidemiology and Cancer Therapy", British Journal of Cancer, 74(Supp. XXVIII), SP17:6.
Wang, X.W., et al. (1995) "p53 modulation of TFIIH-associated nucleotide excision repair activity", Nature Genetics, 10:188-195.
Wang, X.W., et al. (1995) "Abrogation of p53-induced Apoptosis by the Hepatitis B Virus X Gene", Cancer Research 55:6012-6016.
F.ang.hraeus, Robin, et al. (1996) "Inhibition of pRb phosphorylation and cell-cycle progression by a 20-residue peptide derived from p16.sup.CDKN2/INK4A ", Current Biology, 6(1):84-91.
Wang, X.W., et al. (1994) "Interaction with hepatitis B virus X proteins inhibits p53 transcriptional activity and p53 associated with ERCC3", Proceedings of the American Association For Cancer Research, Abstracts 35:585 (3486).
Xiao, Hua, et al. (1994) "Binding of Basal Transcription Factor TFIIH to the Acidic Activation Domains of VP16 and p53", Molecular and Cellular Biology 14(10): 7013-7024.
Schaeffer, L., et al. (1994) "The ERCC2/DNA repair protein is associated with the class II BTF2/TFIIH transcription factor", The EMBO Journal, 13(10):2388-2392.
Wilcock, D., et al. (1991) "Localization pf p53, retinoblastoma and host replication proteins at sites of viral replication in herpes-infected cells", Nature349:429-431.
Harris, C.C., et al. (1993) "Clinical Implications of the p53 Tumor-Suppressor Gene", New England Journal of Medicine, 329:1318-1327.
Wang, X.W., et al. (1994) "Hepatitis B virus X protein inhibits p53 sequence-specific DNA binding, transcriptional activity, and association with transcription factor ERCC3", Proc. Natl. Acad. Sci. USA, 91:2230-2234.
Schaeffer, Laurent, et al. (1993) "DNA Repair Helicase: A Component of BTF2 (TFIIH) Basic Transcription Factor", Science 260:58-63.
Roy, Richard, et al. (1994) "The DNA-dependent ATPase Activity Associated with the Class II Basic Transcription Factor VTF2/TFIIH", The Journal of Biological Chemistry, 269(13):9826-9832.
Rudinger, J. (1976). Peptide Hormones (ed. J.A. Parsons). University Park Press. Baltimore. pp. 1-7.
Wang et al., `The XPB and XPD DNA Helicases are Components of the P53-Mediated Apoptosis Pathway`, Genes & Debelopment, vol. 10, pp.1219-1232, 1996.
Harris Curtis C.
Hoeijmakers Jan H. J.
Wang Xin Wei
Gupta Anish
The United States of America as represented by the Department of
Tsang Cecilia J.
LandOfFree
Screening assays for compounds that cause apoptosis and related does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Screening assays for compounds that cause apoptosis and related , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Screening assays for compounds that cause apoptosis and related will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1324749