Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving hydrolase
Patent
1997-07-18
1999-02-23
Leary, Louise N.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving hydrolase
435 4, 435 721, 435 723, 435 19, 435 21, 436 63, C12Q 134, C12Q 100, C12Q 142
Patent
active
058742352
ABSTRACT:
Nonsteroidal anti-inflammatory drugs cause a dramatic increase in intracellular ceramide, which induces apoptosis. The ceramide increase is likely mediated by cyclooxygenase inhibition, which elevates arachidonic acid, which stimulates sphingomyelinase, which produces ceramide. Contacting members of this pathway with test compounds and observing their effects provides a method of screening for potential cancer chemopreventative agents.
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Chan Timothy A.
Kinzler Kenneth W.
Morin Patrice J.
Vogelstein Bert
Leary Louise N.
The Johns Hopkins University
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