Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2005-04-04
2009-08-11
Pak, Michael (Department: 1646)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S007200, C435S007210, C435S007800, C435S069100, C435S331000, C435S334000, C435S375000, C435S320100, C530S300000, C530S350000, C530S387100, C536S023400, C536S023500
Reexamination Certificate
active
07572594
ABSTRACT:
The present invention provides methods for screening for a molecule that antagonizes or agonizes RANK activity. One aspect of the invention involves the growth of RANK responsive cells in semi-solid medium, wherein exposure to a RANK antagonist promotes colony formation. Other aspects of the invention rely on promoter/reporter constructs using RANK responsive promoters derived from the MMP-9 and TRAP genes. Additional aspects of the invention exploit the ability of RANK to activate c-src activity, F-actin ring formation and CaPO4resorption.
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Ausenhus Scott L.
Basi Nirmal S
Immunex Corporation
Pak Michael
LandOfFree
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