Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2003-06-17
2008-09-23
Kolker, Daniel E. (Department: 1649)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C800S003000
Reexamination Certificate
active
07427489
ABSTRACT:
Screening assays for identifying agents that modulate BK channel activity and further modulate the sleep/wake cycle in a subject, circadian regulated locomotor activity in a subject, or both are provided, as are agents identified using such screening assays. Also provided are methods of modulating the sleep/wake cycle in a subject and methods of modulating circadian regulated locomotor activity in a subject by administering an agent that modulates BK channel activity to the subject, for example, an agent identified by a screening assay as disclosed.
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Ceriani M. Fernanda
Hogenesch John B.
Kay Steve A.
Panda Satchidananda
DLA Piper (US) LLP
IRM LLC
Kolker Daniel E.
The Scripps Research Institute
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