Screening assay for compounds stimulating somatostatin transcrip

Details Screening assay for compounds stimulating somatostatin transcrip Screening assay for compounds stimulating somatostatin transcrip

1996-11-27

1998-12-15

Railey, II, Johnny F.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 4, C12Q 102, C12Q 168

Patent

active

058494936

ABSTRACT:
The present invention provides a method to design compounds that mimic the effects of Pbx in stabilizing STF-1 binding. Using well known DNA binding assays, a person having ordinary skill in this art would be able to screen compounds to determine drugs effective in promoting STF-1 binding to DNA. In this way, one will be able to discover new compounds useful in stimulating somatostatin and insulin production.

REFERENCES:
patent: 5612455 (1997-03-01), Hoey
Olson et al., Proc. Natl. Acad. Sci. USA 92:9127-9131 (1995).

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