Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1995-02-16
1997-06-10
Fitzgerald, David L.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 29, 435 691, 536 235, G01N 3350, C12N 1512
Patent
active
056374704
ABSTRACT:
Disclosed are nucleic acids encoding the .beta. subunit of the mammalian large-conductance ("maxi-K") potassium channel, cells transformed with such nucleic acids, and .beta. subunit proteins produced by the transformed cells. Within the invention are recombinant host cells expressing .alpha..beta. heteromultimers. Such cells or preparations made from them may be used to screen for pharmacologically active modulators of maxi-K channel activity. Such modulators are potentially useful in treating asthma, pregnant human myometrium, hypertension and angina, cerebral ischemia, and conditions where stimulation of neurotransmitter release is desired, such as in Alzheimer's disease and stimulation of damaged nerves.
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Folander Kimberly L.
Garcia Maria L.
Kaczorowski Gregory J.
Leonard Reid J.
McManus Owen B.
Camara Valerie J.
Daniel Mark R.
Fitzgerald David L.
Merck & Co. , Inc.
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