Screening and selection methods for statin drug combinations

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving transferase

Reexamination Certificate

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Reexamination Certificate

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07407772

ABSTRACT:
A method for screening statins in their open acid form to determine the susceptibility of each tested statin to metabolic glucuronidation is provided. Also provided is a method for determining if a non-statin pharmaceutical drug co-administered with a statin that is susceptible to metabolic glucuronidation in its open acid form, will inhibit the glucuronidation of the statin and thereby increase the risk of an adverse drug interaction.

REFERENCES:
patent: 6319678 (2001-11-01), Trubetskoy et al.
patent: WO 02/058732 (2002-08-01), None
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