Screen for sodium channel modulators

Details Screen for sodium channel modulators Screen for sodium channel modulators

2006-08-22

2006-08-22

O'Hara, Eileen (Department: 1646)

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Primate cell, per se

C435S325000, C435S006120, C435S069100, C435S007950, C530S350000

Reexamination Certificate

active

07094600

ABSTRACT:
A method or screen for assessing the potential of a compound to treat a pathological condition, such as arrhythmia, which is manifested by an increased late sodium current in a heart is disclosed. The method employs a mutant sodium channel protein having an amino acid sequence in which one or more amino acids among the ten amino acids occurring at the carboxy end of the S6 segments of D1, D2, D3 or D4 domains of mammalian Nav1 differs from the amino acid in wild-type Nav1 by substitution with tryptophan, phenylalanine, tyrosine or cysteine. Cells transfected with a nucleic acid that encodes a mutant mammalian Nav1 protein, as well as isolated nucleic acids comprising a nucleotide sequence that codes for a mutant mammalian Nav1 protein are disclosed.

REFERENCES:
Wang et al., Mol. Pharmacol. 60: 62-628, 2001.
Bowie et al., Science 247: 1306-1310, 1990.
Wells, Biochemistry 29:8509-8517, 1990.

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