Chemistry: molecular biology and microbiology – Micro-organism – per se ; compositions thereof; proces of... – Fungi
Patent
1997-04-09
1999-11-02
Achutamurthy, Ponnathapura
Chemistry: molecular biology and microbiology
Micro-organism, per se ; compositions thereof; proces of...
Fungi
43525411, 4351721, C12N 116, C12N 1500
Patent
active
059768665
ABSTRACT:
This invention provides novel fungal strains altered in IPC synthase production, and a method for screening for inhibitors of fungal IPC synthase using whole cells.
REFERENCES:
Takashi Hashida-Okada, et al. "AUR1, a novel gene conferring aureobasidin resistance on Saccharomyces cerevisiae: a study of defective morphologies in Aur1p-depleted cells." Mol. Gen. Genet. 215:236-244 (1996).
M. Marek Nagiec, et al. "Sphingolipid Synthesis as a Target for Antifungal Drugs." The Journal of Biological Chemistry 272(15):9809-9817 (Arpr. 11, 1997).
Hashida-Okado et al. "Cloning and Characterization of a gene confering resistance to the antifungal antibiotic aureobasidin A (R106-1) in yeast" Biochemical Pharmacology May 1, 1995; 11: A1371.
Heidler SA, et al. "The AUR1 gene in Saccharomyces cerevisiae encodes dominant resistance to the antifungal agent aureobasidin A (LY295337)" Antimicrob Agents Chemother. Dec. 1, 1995; 39(12): 2765-2769.
Schneider et al. "Vectors for expression of cloned genes in yeast: Regulation, overproduction, and underproduction" Method in Enzymology (Jan. 14, 1991) vol. 194, pp. 373-388.
Baudin A, et al. "A simple and efficient method for direct gene deletion in Saccharomyces cerevisiae" Nucleic Acids Res. Jul. 11, 1993; 21(14): 3329-3330.
Sikorski RS, et al. "A system of shuttle vectors and yeast host strains for designed effieicient manipulation of DNA in Saccharomyces cerevisiae" Genetics. May 1, 1989; 122(1): 19-27.
Heidler Steven Alan
Radding Jeffrey Alan
Young Debra Ann
Achutamurthy Ponnathapura
Eli Lilly and Company
Mayhew Bradley S.
Parker III Raymond S.
Webster Thomas D.
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