Scorpion toxins

Chemistry: molecular biology and microbiology – Process of mutation – cell fusion – or genetic modification

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C536S023500, C435S320100, C435S252300, C435S254110, C435S419000, C435S455000, C435S468000, C435S471000, C435S348000, C435S254200

Reexamination Certificate

active

10614934

ABSTRACT:
This invention relates to an isolated nucleic acid fragment encoding scorpion toxins that are K-channel agonists. The invention also relates to the construction of a chimeric gene encoding all or a portion of the K-channel agonists, in sense or antisense orientation, wherein expression of the chimeric gene results in production of altered levels of the K-channel agonists in a transformed host cell.

REFERENCES:
patent: 4925664 (1990-05-01), Jackson et al.
patent: 0374753 (1989-12-01), None
patent: 0 374 753 (1990-06-01), None
patent: WO 94/28114 (1994-12-01), None
patent: WO 95/03065 (1995-02-01), None
Maria L. Garcia et al, Biochemistry, vol. 33:6834-6839, 1994, Purification and Characterization of Three inhibitors of Voltage-Dependent K + Channels fromLeiurus quinquestriatusvar.hebraeusVenom.
D.L. Marshall et al., Toxicon, vol. 32(11):1433-1443, 1994, Neuromuscular Effects of Some Potassium Channel Blocking Toxins from the Venom of the ScorpionLeiurus quinquestriatus hebreus.
J.M. Sabatier et al., Int. J. Peptide Protein Res., vol. 43:486-495, 1994, Leiurotoxin I, a scorpion toxin specific for Ca2+-activated K+ channels.
Elishu Zlotkin et al., Phytoparasitica, vol. 19(3):177-182, 1991, Venom Neurotoxins—Models for Selective Insecticides.
E. Zlotkin et al., Archives of Biochem. & Biophys., vol. 240(2):877-887, 1985, An Excitatory and a Depressant Insect Toxin from Scorpion Venom both Affect Sodium Conductance and Possess a Common Binding Site.
E. Zlotkin et al., Biochimie, vol. 53:1073-1078, 1971, Purification and properties of the insect toxin from the venom of the scorpionAndroctonus australisHector.
Mark D. Adams et al., Science, vol. 252:1651-1656, 1991, Complementary DNA Seqencing: Expressed Sequence Tags and Human Genome Project.
Garcia et al. Purification and characterization of three inhibitors of voltage-dependent K+ channels fromLeiurus quinquestriatusvar.hebraeusvenom. 1994. Biochemistry 33: 6834-6839.
Marshall et al. Neuromuscular effects of some potassium channel blocking toxins from the venom ofLeiurus quniquestriatus hebraeus. 1994. Toxicin 32(11): 1433-1434.
Norton et al. The cystine knot structure of ion channel toxins and related Polypeptides. Nov. 1998. Toxicon 36 (11) :1573-1583.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Scorpion toxins does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Scorpion toxins, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Scorpion toxins will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3881978

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.