Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2007-03-20
2007-03-20
Weber, Jon (Department: 1652)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
C514S013800, C514S021800, C530S856000, C530S325000, C530S324000
Reexamination Certificate
active
10517097
ABSTRACT:
The present invention provides isoformes from a peptide family belonging to South American scorpionTityus serrulatusthat acts as hypotensive agents by potentiating Bradykinin and, therefore, can be used as anti-hypertensive drugs. A peptide was firstly isolated fromTityus serrulatusvenom and showed a strong and long-lasted hypotensive activity when tested in rats. This peptide was first named TsHpt-I (Tityus serrulatusHypotensin-I). Also, three more highly similar isoformes were identified and revealed a peptide family with very close primary structure. They were named TsHpt-II, TsHpt-III and TsHpt-IV.
REFERENCES:
Result 5 from Geneseq database search, alignment of Seq ID No.: 4 with Seq ID No.: 1839, yseF protein fromLactococcus lactis, Bolotine et al., FR 2807446 A1, searched on Dec. 29, 2005.
Bougis Pierre Edouard
Diniz Carlos Ribeiro
Dos Santos Robson Augusto Souza
Eauclaire Marie-France
Perez-Garcia Maria Elena de Lima
Caesar Rivise Bernstein Cohen & Pokotilow Ltd.
Kosson Rosanne
Universidade Federal de Minas Gerais
Weber Jon
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