Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2000-10-19
2002-04-09
Page, Thurman K. (Department: 1615)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C424S401000, C424S078030, C514S023000, C514S054000, C514S937000, C514S938000, C536S123100
Reexamination Certificate
active
06369217
ABSTRACT:
The present invention relates to new compounds, to processes for the production of the new compounds and to cosmetic compositions containing the new compounds as an active ingredient.
In GB-A-2 050 825 there is described a skin cosmetic composition of the oil-in-water type, comprising an emulsifying agent, an oil and water, the emulsifying agent being composed of a) at least one specified glycyrrhizic compound and b) at least one water-soluble polysaccharide selected from pectin, karaya gum, locust bean gum and xanthan gum.
The polysaccharides used in GB-A-2,050,825 have certain disadvantages, namely that they contain acidic groups, rendering them sensitive to salt formation and/or variations in pH, as well as a lack of stability over an adequate temperature range.
In JP030167109 there is described a cosmetic material containing a &bgr;-1,3-glucan having a mean molecular weight greater than 10×10
6
. &bgr;-1,3-glucans having a mean molecular weight greater than 10×10
6
, however, are of poor aspect, and their molecular weight cannot be determined using the conventional light scattering method.
It has now been found that certain new scleroglucans are useful as active ingredients and as excipients in cosmetic compositions, without the disadvantages associated with the polysaccharides used in GB-A-2,050,825 or with the &bgr;-1,3-glucans of JP030167109. Moreover, the scleroglucans used in the present compositions, on drying, form flexible films which, although insoluble in water, swell readily therein. This ability to form films represents an added advantage for the use of these scleroglucans in cosmetic formulations. Still further, the new scleroglucans have been found to exhibit valuable anti-inflammatory properties, rendering them valuable, for example, as active ingredients in after-sun preparations for the treatment of sun burn.
Accordingly, the present invention provides, as a first aspect, a cosmetic composition comprising:
A) a cosmetically acceptable carrier; and
B) 0.05 to 3.0, preferably 0.2 to 1.0% by weight, based on the weight of the total composition, of a &bgr;-1,3-scleroglucan having a three-dimensional crosslinked triple helix structure and having a mean molecular weight of 1×10
6
to 12×10
6
, preferably 2×10
6
to 10×10
6
.
The cosmetic composition may constitute, e.g., a shampoo and/or hair conditioner composition, in which the scleroglucan component B) may perform one or more of the following functions:
i) effect an improvement in the combability of hair treated with the shampoo/conditioner;
ii) effect an improvement in the dispersion of other components in the shampoo/conditioner;
iii) act as a smoothing agent for hair treated with the shampoo/conditioner; and
iv) effect an improvement in the level of fixing of such additives as dyes or UV absorbers in the shampoo/conditioner.
The cosmetic composition according to the present invention may also constitute a skin care composition, e.g., an emulsion or cream in which the scleroglucan may perform one or more of the following functions:
i) effect a lubricating function, thereby facilitating the spreading of the composition on the skin;
ii) act as a film-forming agent, thereby providing a protective film on the skin, which film, while almost undetectable by touching, provides the skin with a silky feel;
iii) effect a smoothing of the skin by reducing the scaling of the outermost layer of stratum corneum;
iv) effect an anti-inflammatory effect on the skin;
v) effect an improvement in the dispersion of other components of the skin care composition; and
vi) act as an emulsifier or co-emulsifier for the skin care composition.
The skin care composition may be formulated as an aqueous lotion, a water-in-oil or an oil-in-water emulsion, an oil or oil-alcohol lotion, a vesicular dispersion of anionic or nonionic amphiphilic lipids, an aqueous, aqueous-alcohol, alcohol or oil-alcohol gel, a solid stick or an aerosol formulation.
When formulated as a water-in-oil or an oil-in-water emulsion, the cosmetically acceptable carrier A) preferably comprises 5 to 50% of an oil phase; and 47 to 94.95% of water, each based on the total weight of the composition.
The oil phase may comprise any oil, or mixture thereof, which is known to be suitable for use in cosmetic compositions.
Examples of such oils include aliphatic hydrocarbons such as liquid paraffin, squalane, vaseline and ceresin; vegetable oils such as olive oil, almond oil, sesame oil, avocado oil, castor oil, cacao butter and palm oil; animal oils such shark liver oil, cod liver oil, whale oil, beef tallow and butter fat; waxes including bees wax, carnauba wax, spermaceti and lanolin; fatty acids such as lauric acid, myristic acid, palmitic acid, stearic acid, oleic acid and behenic acid; aliphatic alcohols such as lauryl alcohol, stearyl alcohol, cetyl alcohol and oleyl alcohol; and aliphatic esters such as isopropyl-, isocetyl- or octadecyl myristate, butyl stearate, hexyl laurate, diisopropyl adipate or diisopropyl sebacate.
Preferred mono- or polyols, for use in an oil-alcohol lotion, or a an oil-alcohol or alcohol gel, include ethanol, isopropanol, propylene glycol, hexylene glycol, glycerine and sorbitol.
When the &bgr;-1,3-scleroglucan is used as a co-emulsifier, the other emulsifier used may be any emulsifier conventionally used in cosmetic formulations e.g., one or more of an ethoxylated ester of a natural oil derivative such as a polyethoxylated ester of hydrogenated castor oil; a silicone oil emulsifier such as a silicone polyol; an optionally ethoxylated fatty acid soap; an ethoxylated fatty alcohol; an optionally ethoxylated sorbitan ester; an ethoxylated fatty acid; or an ethoxylated glyceride.
The cosmetic composition according to the present invention may constitute an anti-inflammatory skin care preparation, especially an after-sun skin care preparation.
The cosmetic composition according to the present invention may also constitute an oral care preparation, e.g., a dental gel, a denture fixation aid or a tooth paste; a mucosal lubricant formulation such as a vaginal cream or gel; or an ophthalmological preparation such as eye drops; in which the glucan component B) may perform one or more of the following functions:
i) effect lubrication of dry mucosae;
ii) effect thickening of liquid preparations;
iii) effect retention of active ingredients by formation of films on mucosal surfaces; and
iv) effect an improvement in the dispersion of other components in the composition.
When the &bgr;-1,3-scleroglucan is used in an ophthalmological preparation, it may be used together with other components such as:
a) ophthalmological active ingredients e.g. Gentamicin sulphate, Lomefloxacin hydrochloride, Chloramphenicol, Sodium Diclofenac, Potassium Diclofenac, Dexamethason di-sodium phosphate, Naphazolin nitrate, Tetryzolin hydrochloride, Antazolin hydrochloride, Antazolin sulphate, Pilocarpin chloride, Vitamin A-palmitate and zinc sulphate;
b) ophthalmological buffers such as boric acid, borax, acetic acid, sodium acetate, phosphoric acid, sodium dihydrogen phosphate, disodium hydrogen phosphate, sodium phosphate, Trometamol, citric acid and sodium citrate;
c) ophthalmological preservatives such as benzyl, alkylammonium chloride, benzoxonium chloride, chlorhexidine digluconate, chlorobutanol, phenylethyl alcohol and Thiomersal;
d) solvents such as ethanol, glycerol, polyethylene glycol and water or mixtures thereof;
e) solution aids such as Cremophor EL, Cremophor RH, Tween 20 and Tween 80;
f) isotonising agents such as sodium chloride, mannitol and sorbitol,
g) chelate formers such as disodium EDTA;
h) antioxidants such as a-tocopherol acetate, ascorbic acid, N-acetyl-cystine, sodium bisulphite, sodium thiosulphate and propyl gallate; and
i) viscosity-increasing compounds such as methylhydroxypropyl cellulose, saccharose, Carbopol 934P, Carbopol 940, Carbopol 980 and Polaxomer F127.
The cosmetic composition according to the present invention may also be used as lubricant.
The cosmetic composition of the invention may also comprise
Huber Klaus
Maier Thomas
Rau Udo
Schilling Bernhard
Channavajjala Lakshmi
Mansfield Kevin T.
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