Scintillation proximity assay

Details Scintillation proximity assay Scintillation proximity assay

1978-03-27

1981-06-02

Padgett, Benjamin R.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

Molecular bilayer structure

23230B, 424 15, 424 12, G01N 3348, A61K 4300, G01T 100

Patent

active

042711398

ABSTRACT:
A concept and various means of immunological assay are disclosed wherein two different classes of particles which interact at short distances to produce characteristic detectable signals are employed in a modification of the usual latex fixation test. In one embodiment of the concept an aqueous suspension of appropriately coated tritiated latex particles (LH) and polystyrene scintillant particles (L*) is employed. The amount of (LH) (L*) dimer formation and higher order aggregation induced and therefore the concentration of antibody (or antigen) present which caused the aggregation can be determined by using standard liquid scintillation counting equipment.

REFERENCES:
patent: 4000252 (1976-12-01), Kosak

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