Scintillation proximity assay

Details Scintillation proximity assay Scintillation proximity assay

1980-08-04

1983-05-03

Nucker, Christine M.

Chemistry: analytical and immunological testing

Involving immune complex formed in liquid phase

Signal modification or steric inhibition

436804, 436805, G01N 3358, G01N 3360

Patent

active

043820743

ABSTRACT:
An indirect, non-destructive, quantitative assay for the presence of antigens or antibodies in a biological fluid. The assay is based on the interfunctional behavior of a known biological material with the material whose presence is quantitatively sought. In the assay, the known biological material by a correlative action links two discreet interfunctional particles together within a zone of activation with one of the particles emitting light-pulses upon bombardment of electrons from the other particle within the zone of activation. Depending upon which presence is sought to be measured, i.e.; antigen or antibody, the detectable light-pulses give one measurement which gives the ultimate quantitative measurement of the presence of either an antibody or antigen in the biological fluid after their initial interfunctional behavior one to the other. The interfunctional behavior itself is conventional and known in the art.

REFERENCES:
patent: 4271139 (1981-06-01), Hart

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