Schweinfurthin analogues

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C514S100000, C514S378000, C514S397000, C514S414000, C514S454000

Reexamination Certificate

active

07902228

ABSTRACT:
Methods and intermediates for preparing enantiomerically enriched Schweinfurthin analogs which are useful for the treatment of cancer, as well as novel Schweinfurthin analogs having anti-cancer activity, compositions comprising such analogs and therapeutic methods comprising administering such analogs.

REFERENCES:
patent: 7358377 (2008-04-01), Wiemer et al.
International Search Report for International Application No. PCT/US2005/010482, mailed Mar. 30, 2006.
Beutler et al., “Schweinfurthin D, a cytotoxic stilbene fromMacaranga schweinfurthii”, Natural Product Letters, 14(5), 399-404 (2000).
Beutler, J. A. et al., “Cytotoxic Geranyl Stilbenes fromMacaranga schweinfurthii”, Journal of Natural Products, vol. 61, No. 12, 1509-1512, (1998).
Neighbors, JD et al., Synthesis of Nonracemic 3-Deoxyschweinfurthin B, J. Org. Chem., 70, 925-931. (2005).
Thoison, Odile et al., “Plants of New Caledonia. Part 140. Vedelianin, a hexahydroxanthene derivative isolated fromMacaranga vedeliana”, Phytochemistry, vol. 31, No. 4, 1439-1442, (1992).
Treadwell et al., “A cascade cyclization approach to schweinfurthin B”,Organic Letters, 4(21), 3639-3642 (2002).
MSNBC News Service, “Mixed results on new cancer drug”, Nov. 9, 2000.
Freshney, Culture of Animal Cells, A Manual of Basic Technique, Alan R. Liss, Inc., 1983, New York, p. 4.
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Dermer,Bio/Technology, 12, 320 (1994).
MedicineNet.com, Definition of Cancer, 1 page, Aug. 29, 2006.
Thoison et al., “Vedelianin, a hexahydroxanthene derivative isolated fromMacaranga vedeliana”, Phytochemistry, 31(4), 1439-1442 (1992).

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