Schwannomin-binding proteins

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues

Reexamination Certificate

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C530S395000, C530S397000, C536S023100, C536S023500

Reexamination Certificate

active

06960650

ABSTRACT:
In accordance with the present invention, there are provided novel Schwannomin-Binding-Proteins (SBPs). Nucleic acid sequences encoding such proteins and assays employing same are also disclosed. The invention SBPs can be employed in a variety of ways, for example, for the production of anti-SBP antibodies thereto, in therapeutic compositions and methods employing such proteins and/or antibodies. Also provided are transgenic non-human mammals that express the invention protein.

REFERENCES:
Scoles et al. American Journal of Human Genetics. (1996) 59(supplement 4) Abstract A5.
Trofatter et al. Cell. (1993) 72: 791-800.
Takeshima et al. Oncogene (1994) 9: 2135-2144.
Chang et al., “Cloning of a Portion of the Chromosomal Gene and cDNA for Human β-Fodrin, the Nonerythroid Form of β-Spectrin,”Genomics, 17:287-293 (1993).
Dorsey et al., “Merlin Protein—Protein Interactions Revealed by the Two Hybrid System,”Molecular Biology of the Cell, 7:23A, Abstract #137 (1996).
Database Accession No. AAT80430 XP002270087 “WO97/04104”.
Database Accession No. AAT20293 XP002270088 “HUMGS01442”.
Database Accession No. AAT41047 XP002270089 “HUMGS01442 derived sense primer”.
Database Accession No. I32121 XP002270090 “Sequence 11”.
Database Accessioin No. AAT41048 XP002270092 “HUMGS01442 derived anti-sense primer”.
Asano, et al., “Conservation and Diversity of Eukaryotic Translation Initiation Factor eIF3,”J. Biol. Chem., 272(2) :1101-1109 (1997).
Discher et al., “Mechanochemistry of the Alternatively Spliced Spectrin-Actin Binding Domain in Membrane Skeletal Protein 4.1,”J. Biol. Chem., 268(10):7186-7195 (1993).
Subrahmanyam et al., “Phosphorylation of protein 4.1 on tyrosine-418 modulates its function in vitro,”Proc. Natl. Acad. Sci. USA, 88:5222-5226 (1991).
Takeshima et al., “Detection of cellular proteins that interact with the NF2 tumor suppressor gene product,”Oncogene, 9:2135-2144 (1994).
Trofatter et al., “A Novel Moesin-, Ezrin-, Radixin-like Gene Is a Candidate for the Neurofibromatosis 2 Tumor Suppressor,”Cell, 72:791-800 (1993).
Fields and Song, “A novel genetic system to detect protein—protein interactions,”Nature, 340:245-246 (1989).
Fox et al., “On the Role of the Platelet Membrane Skeleton in Mediating Signal Transduction,”J. Biol. Chem., 268(34):25973-25984 (1993).
Nelson et al., “Identification of a Membrane-Cytoskeletal Complex Containing the Cell Adhesion Molecule Uvomorulin (E-Cadherin), Ankyrin, and Fodrin in Madin-Darby Canine Kidney Epithelial Cells,”J. Cell. Biol., 110:349-357 (1990).
Paul et al., “Characterization of Fodrin Interaction with the NF2 Tumor Suppressor Gene Product Schwannomin (merlin) and Varying Strengths of Protein Binding that Correlate with NF2 Patient Phenotypes,”Neurology, 48(3) (suppl.2):A393-A394 (1997).
Rouleau et al., “Alteration in a new gene encoding a putative membrane-organizing protein causes neuro-fibromatosis type 2,”Nature, 363:515-521 (1993).
Sainz et al., “Mutations of the neurofibroatosis type 2 gene and lack of the gene product in vestibular schwannomas,”Human Mol. Genet., 3(6):885-891 (1994).
Scoles et al., “The neurofibromatosis 2 gene product schwannomin interacts with βII-spectrin,”Am. J. of Human Genetics., 59(4 suppl.) Abstract A5 (1996).
Scoles et al., “Identification and Characterization of Interaction Between the NF2 Gene Product Schwannomin and βII-Spectrin,”Mol. Biol. of the Cell, 7(suppl.):386A (1996).
Wei et al., “Molecular cloning and functional analysis of a human DNA encoding anEscherichia coliAlkB homolog, a protein involved in DNA alkylation damage repair,”Nucleic Acids Research, 24: 931-937 (1996).
USB Catalog, Molecular Biology Reagents, p. 166 (1990).
Adams et al., GenBank Accession No.: AA314857.
Adams et al., GenBank Accession No.: AA305985.
Asano et al., GenBank Accession No.: U46025.

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