Schwann cells originating in myeloid interstitial cells

Details Schwann cells originating in myeloid interstitial cells Schwann cells originating in myeloid interstitial cells

2006-01-24

2006-01-24

Lankford, Jr., Leon B. (Department: 1651)

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Method of regulating cell metabolism or physiology

C435S372000, C435S384000, C435S392000, C424S093700

Reexamination Certificate

active

06989271

ABSTRACT:
There is provided a method of inducing bone marrow stromal cells to differentiate into bone marrow stromal cell-derived Schwann cells in vitro, comprising the steps of: collecting bone marrow stromal cells from bone marrow and culturing the cells in a standard essential culture medium supplemented with a serum; adding a reducing agent to the culture medium and further culturing the cells; adding a differentiation inducing agent to the culture medium and further culturing the cells; and adding a cyclic AMP-augmenting agent or a cyclic AMP analogue and/or a glial cell differentiation and survival stimulating factor to the culture medium, and further culturing the cells to obtain the bone marrow stromal cell-derived Schwann cells. There are also provided bone marrow stromal cell-derived Schwann cells obtained thereby and a pharmaceutical composition for neural regeneration that comprises them.

REFERENCES:
patent: 5714385 (1998-02-01), Mather et al.
patent: 6576237 (2003-06-01), Ingham et al.
patent: 2003/0220280 (2003-11-01), Bunge et al.
patent: WO 96/35776 (1996-11-01), None
National Institute of Neurological Disorders and Stroke (NINDS), “Angelman Syndrome Information Page” Dec. 2003, p. 1, accessed Oct. 15, 2004 http://www.ninds.nih.gov/health—and—medical/disorders/angelman.htm.
National Institute of Neurolocial Disorders and Stroke (NINDS), “Dementia With Lewy Bodies Information Page” Feb. 2002, p. 1, accessed Oct. 15, 2004 http://www.ninds.nih.gov/health—and—medical/disorders/dimentiawithlewybodies—doc.htm.
National Institute of Neurological Disorders and Stroke (NINDS), “Alzheimer's Disease Information Page” Sep. 2003, p. 1, accessed Oct. 15, 2004 http://www.ninds.hih.gov/health—and—medical/disorders/alzheimersdisease—doc.htm.
Bosch et al, Journal of Neuroscience, 1989, vol. 9, No. 10, pp 3690-3698.
Jasmin et al, Journal of Neuroscience, 2000, vol. 20, No. 24, pp 9215-9223.
Bunge et al, U.S. Provisional Appl. No. 60/354,306, filed Feb. 7, 2002.
M. Dezawa et al., “Sciatic Nerve Regeneration in Rats Induced by Transplantaion of in Vitro Differentiated Bone-Marrow Stromal Cells,” European Jornal of Neuroscience, vol. 14, pp. 1771-1776, 2001.
G. Kopoen et al., “Marrow Stromal Cells Migrate Throughout Forebrain and Cerebellum, and They Differentiate Into Astrocytes After Injection Intoo Neonatal mouse Brains,” Proc. Natl. Acad. Sci. , vol. 96, pp. 10711-10716, 1999.
J. Sanchez-Ramos, “Adult Bone Marrow Stromal Cells Differentiate Into Neural Cells in Vitro,” Experimental Neurology, vol. 247-256, 2000.
D. Woodbury et al., “Adult Rat and Human Bone Marrow Stromal Cells Differentiate Into Neutrons,” Journal of Neuroscience Research, vol. 364-370, 2000.
Martin E. Schwab et al. (1988) “Oligodendrocytes and CNS Myelin Are Nonpermissive Substrates for Neurite Growth and Fibroblast Spreading in vitro,”Journal of Neuroscience8(7); pp. 2381-2393.
S. Hall et al. (1989) “Electron Microscopic Study of the Interation of Axons and Glia at the Site of Anastomosis Between the Optic Nerve and Cellular or Acellular Sciatic Nerve Gratfts,”Journal of Neurocytology18 ; pp. 171-184.
Diane M. Snow et al. (1990) “Sulfated Proteoglycans in Astroglial Barriers Inhibit Neurite Outgrowth in Vitro,”Experimental Neurology109; pp. 111-130.
E. Blaugrund et al. (1992) “Disappearance of Astrocytes and Invasion of Macrophages Following Crush Injury of Adult Rodent Optic Nerves: Implications for Regeneration,”Experimental Neurology118; pp. 105-115.
Martin Bastmeyer et al. (1994) “Similarities and Differences Between Fish Oligodendrocytes and Schwann Cells in Vitro,”GLIA11; pp. 300-314.
Manuel Vidal-Sanz et al. (1987) “Axonal Regeneration and Synapse Formation in the Superior Colliculus by Retinal Ganglion Cells in the Adult Rat,”Journal of Neruoscience7(9); pp. 2894-2909.
Mari Dezawa et al. (1997) “The Role of Schwann Cells During Retinal Ganglion Cell Regeneration Induced by Peripheral Nerve Transplantation,”Investigative Opthalmology&Visual Science38(7); pp. 1401-1410.
Albert J. Aguayo et al. (1983) “A Potential for Axonal Regeneration in Neurons of the Adult Mammalian Nervous System,”Birth Defects: Original Article Series19(4); pp. 327-340.
Maio S. Chen et al. (2000) “Nogo-A is a Myelin-Associated Neurite Outgrowth Inhibitor and an Antigen for Monoclonal Antibody IN-1,”Nature403 ; pp. 434-439.
M. Taito, professor, Tohoku University, “Studies in Establishing Differentiation Function-Maintaining Cell Lines and Using Them for Reconstruction of Biohistological Function,” NEDO 1999 Teian Kobo Jigyo Seika Hokoku: 97S09-003.
Michael A. Chemousov et al. (1996) “Schwann Cells Secrete a Novel Collagen-like Adhesive Protein that Binds N-Syndecan,”The Journal of Biological Chemistry271(23) pp. 13844-13853.

Affiliated with

Also associated with

Rating

Schwann cells originating in myeloid interstitial cells does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Schwann cells originating in myeloid interstitial cells, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Schwann cells originating in myeloid interstitial cells will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3530742