Schizophrenia related gene

Details Schizophrenia related gene Schizophrenia related gene

2007-05-22

2007-05-22

Saoud, Christine J. (Department: 1647)

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

C435S252300, C435S320100, C530S300000, C536S023500

Reexamination Certificate

active

10071645

ABSTRACT:
The invention relates to polynucleotides of the PAPAP gene, polypeptides encoded by the PAPAP gene, and antibodies directed specifically against such polypeptides. The invention also concerns methods for the treatment or diagnosis of schizophrenia, bipolar disorder or related CNS disorder. The invention also concerns the interaction of PAPAP with schizophrenia candidate gene g34872.

REFERENCES:
patent: 6222027 (2001-04-01), Kaser et al.
Wells, J.A. (1990). Additivity of mutational effects in proteins. Biochemistry 29:8509-8517.
Ngo et al. (1990). Computational complexity, protein structure prediction, and the Levinthal paradox. in Merz and Le Grand (Eds.) The Protein Folding Problem and Tertiary Structure Prediction. Birkhauser:Boston.
Chang, B, et al. “Characterization of a calmodulin kinase II inhibitor protein in brain”; Proceedings of the National Academy of Sciences of the USA, vol. 95, N*18: 10890-5, Sep. 1, 1998.
Chang, B, et al. “Calcium/calmodulin-dependent protein kinase II inhibitor protein : localization of Isoforms in rat brain”; Neuroscience, vol. 102, N*4 : 767-77, 2001.

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