Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Reexamination Certificate
2006-06-27
2006-06-27
Fredman, Jeffrey (Department: 1637)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
C530S412000, C435S069100
Reexamination Certificate
active
07067627
ABSTRACT:
The invention concerns the human sbg1, g34665, sbg2, g35017 and g35018 genes, polynucleotides, polypeptides biallelic markers, and human chromosome 13q31-q33 biallelic markers. The invention also concerns the association established between schizophrenia and bipolar disorder and the biallelic markers and the sbg1, g34665, sbg2, g35017 and g35018 genes and nucleotide sequences. The invention provides means to identify compounds useful in the treatment of schizophrenia, bipolar disorder and related diseases, means to determine the predisposition of individuals to said disease as well as means for the disease diagnosis and prognosis.
REFERENCES:
patent: 6476208 (2002-11-01), Cohen et al.
patent: WO 97/27284 (1997-07-01), None
patent: WO 98/20165 (1998-05-01), None
patent: WO 00/22122 (2000-04-01), None
Shallom et al (J. Biol. Chem. (1999) 31:37781-37786).
Fritzler et al (J. Biol. Chem. (1995) 270(52):31262-31268).
Database Trembl, Accession No. 002586; Llu, et al., “Molecular cloning and expression of the gene encoding a cysteine proteinase of Spirometra erinacei”,Mol. Biochem. Parasitol., 1996, pp. 11-21, vol. 76.
Database Swissprot, Accession No. P12410; McCam, D.F., et al., “Genes encoding the alpha, gamma, delta, and four Fo subunits of ATP synthase constitute an operon in the cyanobacterium Anabaena sp. strain PCC 7120”,J. Bacteriol., 1988, pp. 3448-3456, vol. 170.
Database Geneseq. Accession No, V76530; Barash, S.C. et al., “Polynucleotide(s) and proteins derived fromStapyhloccoccus aureus—stored on computer readable mediums and used in the production of anti-S.aureus vaccines”, 1999, XP002155359, -ABSTRACT.
Database Emest. Accession No. AA388085; Marra, et al., “The WashU-HHMI Mouse EST Project”, 1996, Unpublished.
Database Embl, Accession No. AC008024; Birren, et al., “Homo Sapiens, clone RP11-4584” 1999, XP002176242.
Antonnarakis, et al., “Linkage and sib-pair analysis reveal potential schizophrenia susceptibility gene on chromosome 13q32”,Am. J. Hum. Genet., 1996, p. A210, vol. 59.
Lin, et al., “Suggestive evidence for linkage of schizophrenia to markers on chromosome 13q14.1-q32”,Psychiatric Genetics, 1995, pp. 117-126, vol. 5, Rapid Science Publishers, XP-00094458.
Inayama, et al., “Positive Association Between a DNA Sequence Variant in the Seratonin 2A Receptor Gene and Schizophrenia”,American Journal of Medical Genetics(Neuropsychiatric Genetics), 1996, pp. 103-105, vol. 67; Wiley-Liss, Inc. XP-000944353.
Zhang, et al., “Identification of protein coding regions in the human genome by quadratic discriminant analysis”,Proc. Natl. Acad. Sci. USA. 1997, pp. 565-568. vol. 94; Genetics PNAS; 0027-B424/97/94565-4.
Chee, et al., “Accessing Genetic Information with High-Density DNA Arrays”,Science, 1996, pp. 60-614. vol. 94; XP-002022508.
Detera-Wadleigh, et al., “A high density genome scan detects evidence for a bipolar-disorder susceptibility locus on 13q32 and other potential locl on 1q32 amd 19p11.2”,Proc. Natl. Acad. Sci. USA, May 1999, pp. 5604-5609, vol. 96; XP002134450.
Kruglyak, Leonid, “The use of a genetic map of biallelic markers in linkage studies”,Nature Genetics, 1977, pp. 21-24, vol. 17, No. 1, XP002050647.
Lin, et al. “Suggestive evidence for linkage of schizophrenia to markers on chromosome 13 in Caucasian but not Oriental populations”,Hum. Genet., 1997, pp. 417-420, vol. 99, Springer-Verlag. 1997.
Brzustowicz, et al., “Linkage of Famlllal Schizophrenia to Chromosome 13q32”,Am. J. Hum. Genet., 1999, pp. 1096-1103, vol. 65, The American Society of Human Genetics.
Pulver, et al., “The Johns Hopkins University of Collaborative Schizophrenia Study: An Epidemiologic-Genetic Approach to Test the Heterogeneity Hypothesis and Identify Schizophrenia Susceptibility Genes”,Cold Springs Harbor Symposia on Quantitative Biology, 1996, pp. 797-814, vol. LXI, Cold Springs Harbor Laboratory Press.
Straub, et al., “Genome Scan for Schizophrenia Genes: A Detailed Progress Report in an Irish Cohort”.Am. J. Med. Genet. (Neuropsychiatr. Genet.), (1997) 74:558. -ABSTRACT.
Shaw, et al. “A Genome-Wide Search for Schizophrenia Susceptibility Genes”,American Journal of Medical Genetics(Neuropsychiatric Genetics), 1998, pp. 364-376, vol. 61, Wiley-Liss, Inc.
Osoegawa, et al., “A Bacterial Artificial Chromosome Library for Sequencing the Complete Human Genome”,Genome Research, 2001, pp. 483-496, vol. 11, Cold Spring Harbor Laboratory Press.
RPCI-11 Human Male BAC Library, two pages, http://www.chorl.org/bacpac/hmale11.htm.
Blouin,.et al., Schizophrenia Susceptibility Loci on Chromosomes 13q32 and 8p21,Nature Genetics, 1998, pp. 70-73, vol. 20, No. 1, XP000944108.
Lander, et al., Genetic Dissection of Complex Traits, 1994,Science, pp. 2037-2046, vol. 265.
Osoegawa et al., “An improved approach for construction of bacterial artificial chromosome libraries”,Genomics, pp. 1-8, vol. 52.
Li, S-H et al., “Novel Triplet Repeat Containing Genes in Human Brain: Cloning, Expression, and Length Polymorphisms”,Genomics, 1993, pp. 572-579, vol. 16, No. 3, XP000195589, U.S. Academic Press, San Diego, CA.
Wang, et al., “Large-scale identification, mapping and genotyping of single-nucleotide polymorphisms in the human genome”,Science, 1996, pp. 1077-1082, vol. 280, XP0022089398.
Wright, et al., “Schizophrenia and HLA: A review”,Schizophrenia Research, 2001, pp. 1-12, vol. 47, No. 1.
EMBL Database Accession No. B75361; Adams et al., “Use of BAC and sequences for sequence-ready map building”, 1998, XP002135179, Unpublished.
EMBL/Genbank Databases, Accession No. AA989298, “National Cancer Institute, Cancer Genome Anatomy Project (CGAP), Tumor Gene Index, http://www.ncbi.nlm.gov
cicgap”, XP002135005, Unpublished.
-& EMBL/Genebank Databases, Accession No. L10374, Sequence Reference HSMRNAC, Jun. 1993, XP002134451.
Kruglyak, L. “Passage text. The use of a genetic map of bialielo markers in linkage studies”,Nature Genetics, 1997, pp. 22-24, vol. 17, No. 1, New York, New York, XP002050647, ISSN: 1061-4036.
GENBANK H09867, Jun. 23, 1995.
GENBANK H09780, Jun. 23, 1995.
GENBANK AA424106, Oct. 16, 1997.
GENBANK AA420456, Oct. 16, 1997.
Kashima, et al., “Role of unique consecutive glutamine repeats in active murine interleukin-2 molecule”,J. Biochem., 1987, pp. 726-732, vol. 102.
Wimmer et al., “A drosphilia homologue of human SP1 is a head specific segmentation gene”,Nature, pp. 690-694, vol. 366.
Hanson, et al., “Systemic lupus erthyromatosis patients with central nervous system involvement show autoantibodies to a 50kd neuronal membrane protein”,J. Exp. Med., pp. 565-573, vol. 176.
Bihain Bernard
Blumenfeld Marta
Bougueleret Lydie
Chumakov Ilya
Cohen Daniel
Fredman Jeffrey
Saliwanchik Lloyd & Saliwanchik
Serono Genetics Institute S.A.
LandOfFree
Schizophrenia associated genes, proteins and biallelic markers does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Schizophrenia associated genes, proteins and biallelic markers, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Schizophrenia associated genes, proteins and biallelic markers will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3627322