Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1980-08-13
1981-12-01
Goldberg, Jerome D.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
424258, A61K 31495, A61K 3147
Patent
active
043036597
ABSTRACT:
Certain novel schistosomicidal pharmaceutical compositions are disclosed. These compositions involve the concomitant use of two different organic chemical compounds each chosen from a separate class of known schistosomicidal agents. One class of agents involves certain known 2-aminoalkyl-7-substituted-1,2,3,4-tetrahydroquinolines (A), while the other class is primarily concerned with a series of known 2-acyl-4-oxo-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1a]isoquinoline derivatives (B). A preferred embodiment involves the use of dl-6-hydroxymethyl-2-isopropylaminomethyl-7-nitro-1,2,3,4-tetrahydroquinol ine (A) in conjunction with 2-cyclohexylcarbonyl-4-oxo-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1a]isoqui noline (B). Various methods for administering these compounds in combination and/or in a concomitant manner are provided.
Brammer Keith W.
Shaw John R.
Goldberg Jerome D.
Knuth Charles J.
Murphy Francis X.
Pfizer Inc.
Richardson Peter C.
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