Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1983-11-15
1985-10-01
Daus, Donald G.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
546106, A61K 3147, C07D21908
Patent
active
045446598
ABSTRACT:
Acridanone derivatives of the formula ##STR1## wherein the dotted line is an optional bond, R.sup.1 is hydrogen, halogen or nitro, R.sup.2 is hydrogen or lower alkyl, one of the substituents R.sup.3 and R.sup.4 is hydrogen or lower alkyl and the other together with R is an additional bond and R.sup.5 is hydrogen, lower alkyl, lower alkenyl, lower alkynyl or lower alkyl substituted by halogen or lower alkoxy,
and pharmaceutically acceptable acid addition salts thereof, processes for their preparation and pharmaceutical compositions based thereon, are described. The compounds of formula I are useful as schistosomicidal agents.
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Hunig, et al., Chemical Abstracts, vol. 55, 12857h-12859f (1961).
Zhang, et al., Chemical Abstracts, vol. 93, 239185w (1980).
Ioffe, et al., Chemical Abstracts, vol. 71, 61177a and 70475y (1969).
Elslager, et al., Chemical Abstracts, vol. 72, 3335k (1970).
Bretschneider Hermann
Brombacher Urs
Montavon Marc
Schantl Joachim
Turk Wolfgang
Boxer Matthew
Daus Donald G.
Hoffman-La Roche Inc.
Leon Bernard S.
Rivers Diana G.
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