Scavenger receptors

Details Scavenger receptors Scavenger receptors

2007-03-13

2007-03-13

Priebe, Scott D. (Department: 1633)

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

C435S007100, C435S449000, C424S185100

Reexamination Certificate

active

10203860

ABSTRACT:
Novel scavenger receptors having an SR structure and a collectin-like structure are provided, which can be utilized in the elucidation of mechanisms of macrophage and basic immunity; in the elucidation of mechanisms of the development of a wide variety of diseases such as arteriosclerosis, diabetic complications and Alzheimer's disease, hyper β-lipoproteinemia, hypercholesterolemia, hypertriglyceridemia, hypo α-lipoproteinemia, transplantation, atherectomy, post angiogenic restenosis, bacterial infections; in the diagnostic, prophylactic and therapeutic methods thereof; and in the development of reagents and drugs for the same. The novel scavenger receptors include proteins comprising an amino acid sequence set out in SEQ ID NO: 2, 4 or 24 or proteins having equivalent properties to the same, or derivatives or fragments thereof as well as isolated polynucleotides comprising a nucleotide sequence encoding these proteins, and related molecules such as antibodies, antagonists and the like. Also disclosed are methods for the treatment using the same.

REFERENCES:
patent: 4906734 (1990-03-01), Jensenius
patent: 5270199 (1993-12-01), Ezekowitz
patent: 0 856 580 (1998-08-01), None
patent: HEI-238683 (1997-09-01), None
patent: 10-237611 (1998-08-01), None
patent: WO-89/01519 (1989-02-01), None
patent: WO 98/55614 (1998-12-01), None
patent: WO 99/37767 (1999-07-01), None
patent: WO 00/11161 (2000-03-01), None
patent: WO 00/11161 (2000-03-01), None
patent: WO-00/68380 (2000-11-01), None
patent: WO 01/81401 (2001-11-01), None
Adams et al., “Initial Assessment of Human Gene Diversity and Expression Patterns Based Upon 83 Million Nucleotides of cDNA Sequence,” Nature 377 (Supp): 3-174 (Sep. 1995).
Bork et al. Powers and pitfalls in sequence analysis: the 70% hurdle Genome Res. Apr. 2000 10(4):398-400.
Botas et al., “Altered surfactant homeostasis and alveolar type II cell morphology in mice lacking surfactant protein D,” Proc. Natl. Acad. Sci. USA 95: 11869-11874 (1988).
Database Assession No. R78202 (XP-002242031), Database EMBL Online, EBI (2003).
Database EMBL, Online!,Homo sapienschromosome 18, Nov. 22, 1999, XP002279619.
Doetschman T. Interpretation of phenotype in genetically engineered mice Lab Anim Sci. STET 1999;49(2):137-43.
Drickhamer, K. “Two Distinct Classes of Carbohydrate-recognition Domains in Animal Lectins,” The Journal of Biological Chemistry 263 (20): 9557-9560 (1988).
Epstein et al., “The collectins in innate immunity,” Current Opinion in Immunology, 8:29-35 (1996).
Ezekowitz, R. A. B. et al., “A Human Mannose-binding Protein is an Acute-phase Reactant that Shares Sequence Homology with Other Vertebrate Lectins,” J. Exp. Med., 167:1034-1046 (Mar. 1988).
Ezekowitz, R. A. B. et al., “Mannose-binding protein and susceptibility to chronic hepatitis B infection,” The Lancet, 348: 1396-1397 (Nov. 1996).
Fujita, T. “Complement Activation and Lectin Pathway,” Rinsho-Meneki, 29(3): 405-410 (1997). (Japanese with English abstract translation).
Garred, et al., “Susceptibility to HIV infection and progression of AIDS in relation to variant alleles of mannose-binding lectin,” The Lancet, 349:236-240 (Jan. 1997).
Hakansson et al, Collectin structure: a review. Protein Sci. Sep. 2000;9(9):1607-17.
Hansen et al. Structural aspects of collectins and receptors for collectins Immunobiology. Aug. 1998;199(2):165-89.
Hoppe et al., “Collectins-soluble proteins containing collagenous regions and lectin domains-and their roles in innate immunity,” Protein Science 3: 1143-1158 (1994).
Kawai, T. et al., “Cloning and characterization of a cDNA encoding bovine mannan-binding protein,” Gene, 186(2):161-165 (Feb. 1997).
Kurata, H., “Structure and Function of Mannan-Binding Proteins Isolated from Human Liver and Serum,” J. Biochem., 115(6):1148-1154 (1994).
Laursen et al., “Cloning and sequencing of a cDNA encoding chicken mannan-binding lectin (MBL) and comparison with mammallan analogues,” Immunology 93:421-430 (1998).
Lim, B. L. et al., “Primary Structure of Bovine Collectin-43 (CL-43). Comparison with conglutinin and lung surfactant protein-D,” J. Biol. Chem., 269(16):11820-11824 (Apr. 1994).
Lipscombe, R. J. et al., “Mutations in the Human Mannose-Binding Gene: Frequencies in several population groups,” European Journal of Human Genetics, 4(1): 13-19 (1996).
Lu et al., “Purification, characterization and cDNA cloning of human lung surfactant protein D,” Biochem. J., 284: 795-802 (1992).
Malhortra et al., “Glycosylation changes of IgG associated with rheumatoid arthritis can activate complement via the mannose-binding protein,” Nature Medicine, 1(3): 237-243 (Mar. 1995).
Malhortra et al., “Interaction of C1q receptor with lung surfactant protein A*,” Eur. J. Immun., 22: 1437-1445 (1992).
Matsuda, M. et al., “Involvement of Mannan Binding Protein in Incidence and Development of IgA Nephropathy,” Journal of Nephrology Association of Japan, 39(3): 235 (1997). (Japanese with English abstract translation).
Nakamura et al. Molecular cloning of a mouse scavenger receptor with C-type lectin (SRCL) (1), a novel member of the scavenger receptor family. Biochim Biophys Acta. Nov. 11, 2001;1522(1):53-8.
Nepomuceno, R. R. et al., “cDNA Cloning and Primary Structure Analysis of ClqR(P), the Human C1q/MBL/SPA Receptor That Mediates Enhanced Phagocytosis In Vitro,” Immunity, 6(2):119-129 (Feb. 1997).
Ohtani et al. The membrane-type collectin CL-P1 is a scavenger receptor on vascular endothelial cells J Biol Chem. Nov. 23, 2001;276(47):44222-8.
Ohtani et al., “Molecular Cloning of a Novel Human Collectin from Liver (CL-L1),” Journal of biological Chemistry, 274 (19):13681-13689, May 7, 1999.
Sastry, K. et al., “The Human Mannose-binding Protein Gene: Exon Structure Revelas its Evolutionary Relationship to a Human Pulmonary Surfactant Gene and Localization to Chromosome 10,” J. Exp. Med., 170:1175-1189 (Oct. 1989).
Skolnick et al. From genes to protein structure and function: novel applications of computational approaches in the genomic era. Trends Biotechnol. Jan. 2000;18(1):34-9.
Smith et al. The challenges of genome sequence annotation or the devil is in the details Nat Biotechnol. Nov. 1997:15(12):1222-3.
Sumiya et. al., “Mannose-binding protein, genetic variants and the risk of infection,” Q. J. Med., 89: 723-726 (1996).
Sumiya et. al., “Molecular basis of opsonic defect in immunodeficient children,” Lancet, 337: 1569-1570 (Jun. 1991).
Super et. al., “Association of Low Levels of Mannan-binding Protein with a Common Defect of Opsonisation,” Lancet, 2: 1236-1239 (Nov. 1989).
Supplementary European Search Report , European Patent Office, Jun. 2, 2003.
Supplementary European Search Report for EP 01 90 2805 dated Jun. 3, 2004.
Suzuki et al., “Cloning and Sequencing of a cDNA Coding for Bovine Conglutinin,” Biochem Biophys Res Commun, 191/2, 335-342 (1993).
Suzuki et al., “Characterization of Recombinant Bovine Conglutinin Expressed in a Mammallan Cell,” Biochem. Biophys. Res. Commun., 238: 856-863 (1997).
Tan et al., “Improvements on the Purification of Mannan-Binding Lectin and Demonstration of its Ca2+-independent Association with a C1s-Like serine Protease,” Biochem. J. 391:329-332 (1996).
Taylor, M. E. et al., “Structure and evolutionary origin of the gene encoding a human serum mannose-binding protein,” Biochem J., 262: 763-771 (1989).
Thomas et al., “Mutation of gene for mannose-binding protein associated with chronic hepatitis B viral infection,” Lancet, 348: 1417-1419 (Nov. 1996).
Uemura, K. et al., “Structure-Function Relationships in the Calcium-Dependent Animal Lectins Involved in Biophylaxis,” Jikken-Igaku, 13(18): 46-51 (2156-2161) (1995). (Japanese with English abstract tran

Affiliated with

Also associated with

Rating

Scavenger receptors does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Scavenger receptors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Scavenger receptors will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3744401