Scanning ion conductance microscopy for the investigation of...

Scanning-probe techniques or apparatus; applications of scanning – General aspects of spm probes – their manufacture – or their... – Probe characteristics

Reexamination Certificate

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C250S428000, C422S068100, C422S501000, C422S502000, C073S104000, C073S105000, C435S004000

Reexamination Certificate

active

08006316

ABSTRACT:
A method for interrogating a surface using scanning probe microscopy comprises bringing a scanning probe into proximity with the surface and controlling the position of the probe relative to the surface to maintain a constant distance, characterized in that pressure is applied to the surface by a regulated flow of liquid through the probe, with subsequent monitoring of the position of the probe, wherein movement of the probe indicates a consequent movement of the surface.

REFERENCES:
patent: 7596990 (2009-10-01), Su et al.
patent: 2006/0000263 (2006-01-01), Su et al.
patent: 2009/0222958 (2009-09-01), Su et al.
patent: 09251979 (1997-09-01), None
patent: WO 00/63736 (2000-10-01), None
patent: WO 02/102504 (2002-12-01), None
patent: WO 2004/023490 (2004-03-01), None
Klenerman, D. et al. “Potential biomedical applications of the scanned nanopipette”Nanomedicine, 2006, pp. 107-114, vol. 1, No. 1.
Korchev, Y.E. et al. “Scanning Ion Conductance Microscopy of Living Cells”Biophysical Journal, Aug. 1997, pp. 653-658, vol. 73.
McCarter, G.C. et al. “Mechanical transduction by rat dorsal root ganglion neurons in vitro”Neuroscience Letters, 1999, pp. 179-182, vol. 273.
Sánchez, D. et al. “Localized and non-contact mechanical stimulation of dorsal root ganglion sensory neurons using scanning ion conductance microscopy”Journal of Neuroscience Methods, 2007, pp. 26-34, vol. 159.

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