Scanning agent composition and use in imaging liver and for bili

Details Scanning agent composition and use in imaging liver and for bili Scanning agent composition and use in imaging liver and for bili

1974-12-16

1977-03-01

Padgett, Benjamin R.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

Attached to antibody or antibody fragment or immunoglobulin;...

260112R, A61K 2900, A61K 4300

Patent

active

040102513

ABSTRACT:
A composition to be used in a method for imaging liver and for biliary function, the composition comprising a scanning agent that is combined with a radioisotope. The scanning agent is preferably a glycoprotein whose glycosidic side chains terminate in a sialic acid moiety followed by a galactose as exemplified by gamma globulin. The preferred radioisotope is technetium (.sup.99m Tc).
The composition of the invention will bind to hepatocyte (liver cell) membranes whereas most known pertechnetated hepatic scanning agents attach to the reticuloendothelial cells of the liver (Kuppfer cells) with the advantage being that the present composition will be excreted into the bile ducts and make its way to the intestines, thus acting as an indicator of biliary tree patency.
The composition has been administered to human subjects and animals for liver imaging using the anger camera as well as for evaluating the biliary function.

REFERENCES:
morell, et al., Journal of Biological Chemistry, vol. 246, No. 5, Mar. 10, 1971, pp. 1461-1467.
Gregoriadis, et al., Journal of Biological Chemistry, vol. 245, No. 21, Nov. 19, 1970, pp. 5833-5837.
Heusser, NSA, vol. 27, No. 9, May 15, 1973, Abstract No. 20200.
Lin, et al., NSA, vol. 30, No. 7, Oct. 15, 1974, Abstract No. 19055.
Wells, NSA, vol. 24, No. 1, Jan. 15, 1970, Abstract No. 773.

Affiliated with

Also associated with

Rating

Scanning agent composition and use in imaging liver and for bili does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Scanning agent composition and use in imaging liver and for bili, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Scanning agent composition and use in imaging liver and for bili will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1352993