Scalable process for the preparation of a rapamycin 42-ester...

Details Scalable process for the preparation of a rapamycin 42-ester... Scalable process for the preparation of a rapamycin 42-ester...

2006-12-06

2009-11-24

Kifle, Bruck (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

Reexamination Certificate

active

07622578

ABSTRACT:
A scalable process for the preparation of a rapamycin 42-ester by reacting a rapamycin 42-ester boronate with a diol and purifying crude rapamycin 42-ester by recrystallization and treatment with a diol is provided. Also provided is a method for isolating and purifying a rapamycin 42-ester boronate from mother liquors comprising acetone and rapamycin contaminants.

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